DataSheet_1_An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation.docx by Moira Ek (19350559)

“…Such mutations lead to decreased plasma and cerebrospinal fluid levels of progranulin (PGRN), a neurotrophic factor with lysosomal functions. …”

Reappraisal of the Trophic Ecology of One of the World’s Most Threatened Spheniscids, the African Penguin by Maëlle Connan (680842)

“…The world population of the endangered African penguin <i>Spheniscus demersus</i> has decreased from more than 1.5 million individuals in the early 1900s to c.a. 23 000 pairs in 2013. …”

STRATEGIES FOR STEM MEASUREMENT SAMPLING: A STATISTICAL APPROACH OF MODELLING INDIVIDUAL TREE VOLUME by Hassan Camil David (5632220)

“…In addition, residuals of volume estimates were examined by means of statistical tests of bias, autocorrelation and heteroscedasticity. …”

File S1 - Different Effects of Guanine Nucleotides (GDP and GTP) on Protein-Mediated Mitochondrial Proton Leak by Andrzej M. Woyda-Ploszczyca (574022)

“…Different amounts of protein (50 or 100 µg) were loaded into each lane (as indicated).…”

Dominant negative Rac1 inhibits the H₂S-induced reorganization of the actin cytoskeleton in HUVECs. by Li-Jia Zhang (308411)

“…Scale bars, 10 µm. (C, D) Rac1 siRNA decreased the expression of Rac1 both on the mRNA levels (C) and protein levels (D). …”

<i>nr2f1a</i> modulates the expression of vascular markers. by Bao-Jueng Wu (621818)

“…In addition, expression of the arterial marker <i>ephrinb2</i> (<b>H</b>) and pan-vascular marker <i>stabilin</i> decreased (<b>B</b>). (<b>I</b>) Quantification of the relative expression level by qPCR assay showed a ∼25% to 50% reduced expression in vascular markers <i>flt4</i> (0.66±0.14), <i>EphB4</i> (0.46±0.08), <i>gridlock</i> (0.73±0.06) and <i>ephrinb2</i> (0.59±0.05) in <i>nr2f1a</i> morphants. *** refers to p<0.0001, ** refers to p<0.001 and * refers to p<0.05 by an unpaired student’s t-test. …”

Psychosine affects cell surface area by vesiculation. by Ludovic D’Auria (4040171)

“…Results are mean ± SEM. NS, not significant (>0.05); *, <i>p</i> <0.05; **, <i>p</i> <0.01; ***, <i>p</i> <0.001.…”

Data Sheet 1_Machine learning assisted breathomic approach for early-stage thoracic cancer detection.docx by Zhenguang Chen (518931)

“…Additionally, in a cohort of 58 cancer patients, model-predicted risk significantly decreased post-surgery (p < 0.01), indicating a strong correlation with disease burden reduction.…”

EGCG inhibits PGE₂ receptors-induced human melanoma cell migration. by Tripti Singh (340030)

“…<p>(<b>A</b>) Treatment of A375 melanoma cells with EGCG for 24 h decreases the expression levels of PGE₂ receptors EP2 and EP4 in a concentration-dependent manner. …”

Evolution of inflammatory cytokine levels correlates with clinical and biological manifestations of sirolimus-induced inflammatory syndrome. by Fanny Buron (105196)

Effects of the <i>FABP4</i> gene on steroid hormone secretion in goose ovarian granulosa cells by R. Fan (9655924)

“…Likewise, the mRNA and protein expression levels of <i>CYP11A1</i> and <i>CYP19A1</i> were significantly lower than in the control group (P < 0.001, or P < 0.01).…”

The best responses of the fish and of the manager. by Monica Salvioli (10011163)

Cell-to-cell mtDNA variability for larger mtDNA populations. by Robert C. Glastad (10692277)

“…Normalised heteroplasmy variance <i>V</i>′(<i>h</i>) (left column) and copy number variance <i>V</i>(<i>N</i>) (right column) for mtDNA randomly distributed in networks. <b>A</b>: simulations for <i>h</i> = 0.1; <b>B</b>: simulations for <i>h</i> = 0.5; <b>C</b>: sum over state variables for <i>h</i> = 0.5; <b>D</b>: first-order Taylor expansion for <i>h</i> = 0.5. …”

Embryo morphology and developmental delay–heart rate–morphology correlations of sensitive and resistant embryos exposed to clean and polluted sediment extract. by Goran Bozinovic (8410878)

“…Green curves are regression lines indicating the correlation between the specified variables; corresponding R² values, coefficients of determination, represent the strength of the correlations. a: Developmental Delays–Morphology, b: Heart Rate–Morphology, and c: Heart rate–Developmental Delays correlations among i) sensitive embryos, ii) resistant embryos, iii) both embryo populations. bi) shows as sensitive embryos become more deformed and their morphology scores increase, their heart rates significantly decreased (R² = 0.78); ai) shows morphological deformities also caused significant development delays (R² = 0.82), characterized by ci) altered heart rate (R² = 0.65). …”

Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells by Luis Rodrigo Cataldo (3701206)

Long-term pharmacological inhibition of mTOR signaling impairs retinal growth. by Fangfang Lu (664493)

“…(F) Quantification of retinal size of larvae treated with DMSO, rapamycin, or INK128 from 4dpf-5dpf (short-term) showed comparable overall size between inhibitor- and DMSO-treated groups. p-values: * ≤ 0.05, ** ≤ 0.01. Statistical information can be found in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009628#pgen.1009628.s017" target="_blank">S9 Table</a>. …”

The effects of forskolin on TNF-α secretion by LPS-treated RT4-D6P2T cells. by Caitlyn Henry (18388577)

“…<p>The immortalized rat RT4-D6P2T Schwann cell line (ATCC #CRL-2768) was treated with 0.1, 1, or 10 μg/mL of LPS in N₂ media, with or without 2 μM of forskolin, for 3 hours. …”

Significantly variable serum amino acid and gamma-glutamyl amino acid metabolites. by Patrick C. Barko (10668358)

“…Plots are annotated with the false discovery rate-adjusted p-values (P_adj) derived from the post-hoc pairwise comparisons among storage conditions: q < 0.05 (*); q ≤ 0.01 (**); q ≤ 0.001 (***); q≤ 0.0001 (****). …”

Total history dependence and information timescale for increasing branching parameter <i>m</i>. by Lucas Rudelt (4059505)

An <i>in silico</i> invasion assay allows us to assess invasion outcomes. by Helen M. Kurkjian (3247230)