Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD by Na Jiao (10056370)

“…NAFLD microbiota exhibited decreased diversity and microbial associations. We established a classifier model with 53 differential species exhibiting a robust diagnostic accuracy (AUC=0.97) for dectecting NAFLD. …”

A Genetically Hard-Wired Metabolic Transcriptome in <em>Plasmodium falciparum</em> Fails to Mount Protective Responses to Lethal Antifolates by Karthikeyan Ganesan (269200)

“…No genes were reproducibly up-regulated by more than 2-fold until 24 h after initial drug exposure, even though clonal viability decreased by 50% within 6 h. We predicted and showed that while the parasites do not mount protective transcriptional responses to antifolates in real time, <em>P. falciparum</em> cells transfected with human DHFR gene, and adapted to long-term WR99210 exposure, adjusted the hard-wired transcriptome itself to thrive in the presence of the drug. …”

Rescue the Failed Half-ZFN by a Sensitive Mammalian Cell-Based Luciferase Reporter System by Weifeng Zhang (134361)

“…Our results showed that this system increased the screening sensitivity up to 50-fold and markedly amplified the differences in the binding activities between different ZFPs. …”

Image1.PDF by Shiori Yabe (3172620)

“…To indirectly select for seed yield per unit area, which cannot be measured on a single-plant basis, a selection index was constructed from seven agro-morphological traits measurable on a single plant basis. Over 3 years, we performed two GS and one PS cycles per year for improvement in the selection index. …”

Datasheet1_Butyrate suppresses experimental necrotizing enterocolitis–induced brain injury in mice.pdf by Maribel Martinez (485567)

“…Background<p>Necrotizing enterocolitis (NEC) is a devastating disease in premature infants, and 50% of infants with surgical NEC develop neurodevelopmental defects. …”

Image_2_Functional Analysis of the Chemosensory Protein MsepCSP8 From the Oriental Armyworm Mythimna separata.png by Aneela Younas (5093378)

“…In order to investigate the functions of CSPs in the oriental armyworm Mythimna separata, in the present study we explored expression patterns and binding characteristics of the CSP, MsepCSP8. …”

Image1_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.tiff by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

The Influence of Life History and Sexual Dimorphism on Entheseal Changes in Modern Humans and African Great Apes by Marco Milella (633432)

“…The aim of the present work is to compare age trajectories and patterns of sexual dimorphism in entheseal changes between modern humans and African great apes. To this end we analyzed 23 postcranial entheses in a human contemporary identified skeletal collection (N = 484) and compared the results with those obtained from the analysis of <i>Pan</i> (N = 50) and <i>Gorilla</i> (N = 47) skeletal specimens. …”

Vertically and Horizontally Drawing Formation of Graphite Pencil Electrodes on Paper by Frictional Sliding for a Disposable and Foldable Electronic Device by Junseo Kim (9920910)

“…Repetitive drawing in one-way direction reduced the roughness of the paper surface, decreasing the grain boundaries of graphite. This increases the electron pathway at the electrode, thus reducing the resistance to less than 50 Ω. …”

Table 3_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

DataSheet_1_Proteomic and metabolomic analysis on cadmium-induced mitochondrial toxicity in liver tissues of juvenile olive flounder Paralichthys olivaceus.pdf by Zhen Lu (266590)

“…Our previous study proved that Cd could induce gill mitochondrial toxicity in marine animals. Herein, we aimed to elucidate the toxicity mechanism of Cd on liver mitochondria, as liver is the main metabolic and detoxification organ and generally rich in mitochondria.…”

PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27^Kip1 by Courtney Nicholas (143905)

“…<div><p>Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating the growth of human melanoma cells. …”

<b>Complex relationship between habitat extent and fragmentation in recovering landscapes: The case of the giant panda</b> by Andrés Viña (3120402)

“…Results show that fragmentation not only decreased but also increased with habitat recovery. …”

Iron oxide nanoparticles alleviate salt-alkaline stress and improve growth by modulating antioxidant defense system in cherry tomato by Raheel Shahzad (9700705)

“…This study explores the application of iron oxide nanoparticles (FeONPs) to mitigate salt-alkaline stress in cherry tomatoes. We investigated FeONPs at three concentrations (FeONP25, FeONP50, FeONP100 mg/kg soil) in pot experiments under non-stress (NS) and salt-alkaline stress (SAS) conditions. …”

EMMPRIN Promotes Angiogenesis, Proliferation, Invasion and Resistance to Sunitinib in Renal Cell Carcinoma, and Its Level Predicts Patient Outcome by Mototaka Sato (461331)

“…</p> <p>Experimental Design</p><p>EMMPRIN expression was examined in 50 RCC patients treated with radical nephrectomy. …”

Image 3_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Analysis of Genome-Wide Changes in the Translatome of Arabidopsis Seedlings Subjected to Heat Stress by Emilio Yángüez (447643)

“…For the majority of mRNAs, translation is severely repressed, causing a decreased of 50% in the association of the bulk of mRNAs to polysomes. …”

Vertically and Horizontally Drawing Formation of Graphite Pencil Electrodes on Paper by Frictional Sliding for a Disposable and Foldable Electronic Device by Junseo Kim (9920910)

“…Repetitive drawing in one-way direction reduced the roughness of the paper surface, decreasing the grain boundaries of graphite. This increases the electron pathway at the electrode, thus reducing the resistance to less than 50 Ω. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Different Growth and Physiological Responses to Cadmium of the Three <i>Miscanthus</i> Species by Haipeng Guo (582824)

“…To determine any differences in resistance of <i>Miscanthus</i> to Cd, we examined plant growth, net photosynthetic rate (Pn), activities of anti-oxidant and C₄ photosynthetic enzymes, concentrations of Cd in leaves and roots, and observed the chloroplast structure in three <i>Miscanthus</i> species treated with 0, 10, 50, 100 or 200 μM Cd in solutions. …”