2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

“…Although high concentrations of 2-ethylhexyl diphenyl phosphate (EHDPP) have been detected in wild fish, its reproductive toxicity in fish remains unclear. In this study, we for the first time observed that EHDPP elicited androgen receptor (AR) antagonistic activity with a 50% inhibitory concentration of 37.5 μM. 2-Ethyl-5-hydroxyhexyl diphenyl phosphate was proved to be the dominant metabolite of EHDPP in Japanese medaka and elicited 3.1-fold stronger AR antagonistic activity than that of EHDPP. …”

Table_3_Species-specific metabolome changes during salinity downshift in sub-Arctic populations of Mytilus edulis and M. trossulus.docx by Inna M. Sokolova (3857770)

“…Taurine emerged as the dominant osmolyte, comprising over 50% of the total free amino acid pool, with aspartate and glycine contributing 15–30%. …”

Androgen Receptor Functional Analyses by High Throughput Imaging: Determination of Ligand, Cell Cycle, and Mutation-Specific Effects by Adam T. Szafran (269691)

“…</p><h3>Methodology/Principal Findings</h3><p>We report the development of a high throughput (HT) image-based assay that quantifies AR subcellular and subnuclear distribution, and transcriptional reporter gene activity on a cell-by-cell basis. …”

Video_1_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…However, how NET formation is triggered by HIV in different tissues and whether this mechanism is affected by aging remain unknown. We demonstrate that the mechanisms that trigger NET release in response to HIV are different in blood and genital tissues, and that NET release decreases with aging. …”

Table_1_A Label-Free Quantitative Proteomic Analysis of Mouse Neutrophil Extracellular Trap Formation Induced by Streptococcus suis or Phorbol Myristate Acetate (PMA).DOC by Xiaoping Wang (110673)

“…Of these peptidases, MMP-8 expression was obviously decreased in response to PMA, but it was not significantly changed in response to S. suis. …”

Table_1_Photosynthetic response of Chlamydomonas reinhardtii and Chlamydomonas sp. 1710 to zinc toxicity.DOCX by Di Zhan (14842687)

“…The results demonstrated that Chlamydomonas sp. 1710 was much more tolerant to Zn than C. reinhardtii, with the half-maximal inhibitory concentration (IC50) values of 225.4 mg/L and 23.4  mg/L, respectively. …”

Video_4_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…However, how NET formation is triggered by HIV in different tissues and whether this mechanism is affected by aging remain unknown. We demonstrate that the mechanisms that trigger NET release in response to HIV are different in blood and genital tissues, and that NET release decreases with aging. …”

Presentation_1_Neoadjuvant osimertinib and chemotherapy for stage IIIA primary pulmonary carcinosarcoma with EGFR 19DEL mutation: A case report.pptx by Hongming Wang (11756)

“…After the tumor load and size had significantly decreased, radical surgery was successfully performed under thoracoscopy. …”

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease by Nan Zhang (46264)

“…Compared with mild HFMD, severe HFMD exhibited significantly decreased diversity and richness of gut microbiota. …”

Novel ENU-Induced Mutation in <i>Tbx6</i> Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat by Koichiro Abe (39866)

“…However, the variant has decreased transcriptional activation potential in response to Notch-mediated signaling. …”

Image_5_Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.tif by Yali Sun (2099593)

“…</p>Results<p>Sivelestat administration significantly improved the survival of septic rats (80% vs 50%, P = 0.047). Microbiome analysis showed that the microbiota composition of rats in the CLP group was significantly disturbed, as potential pathogens such as Escherichia-Shigella and Gammaproteobacteria became dominant, and the beneficial microbiota represented by Lactobacillus decreased. …”

A ¹H-NMR Based Study on Hemolymph Metabolomics in Eri Silkworm after Oral Administration of 1-Deoxynojirimycin by Ming-Jie Deng (765440)

“…<div><p>We aimed to investigate whether 1-deoxynojirimycin (DNJ) modulates glycometabolism and has toxicity in Eri silkworm (<i>Samia cynthia ricini</i>, Saturniidae). …”

Image_2_Vitamin A deficiency in the MENA region: a 30-year analysis (1990–2019).JPEG by Saeid Safiri (3713035)

“…The age-standardized prevalence [50.3% (−55.9 to −44.7)] and YLD [−49.3% (−55.3 to −43.1)] rates of VAD have significantly decreased since 1990. …”

Image_5_Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.TIF by María Teresa Soto-Navarrete (3202896)

“…<p>Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. …”

1,3,2-Dioxathiolane 2,2-Dioxide as a Bifunctional Electrolyte Additive to Enhance the Stability of Lithium Metal Anodes by Yi-Xin Huang (7405004)

“…In general, the DTD molecule not only changes the Li-ion solvation structure but also optimizes the SEI component, which decreases the energy barrier for Li deposition and reduces the generation of “dead Li”. …”

Table 1_Proteome changes during in vitro culture adaptation of Toxoplasma gondii archetypal II and III field isolates.xlsx by Joachim Müller (265589)

“…Few reports exist on the molecular bases that govern this adaptation. Herein, we analyzed the T. gondii proteomes of different isolates at two timepoints during cell culture adaptation.…”

Data_Sheet_1_Empowering a Methanol-Dependent Escherichia coli via Adaptive Evolution Using a High-Throughput Microbial Microdroplet Culture System.xlsx by Jia Wang (51945)

“…Given the automatic high-throughput selection of the MMC, a three-stage regime of an adaptive evolution experiment via gradually decreasing the availability of gluconate during the cultivation was performed for 50 days continuously in order to obtain the mutations. …”

Video 2_Case Report: Intra-articular injection of tocilizumab for arthritis treatment in chronic graft-vs.-host disease.mp4 by Mingyu Xie (13868310)

“…Subsequently, we shall present a case of a juvenile patient with arthritis and cGVHD, who responded well to intra-articular injection of tocilizumab, after bone marrow transplantation.…”

Image_1_Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.TIF by María Teresa Soto-Navarrete (3202896)

“…<p>Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. …”

Biomass Accumulation and Carbon Sequestration in Four Different Aged <i>Casuarina equisetifolia</i> Coastal Shelterbelt Plantations in South China by Faming Wang (470716)

“…Soil organic C (SOC) at the top 1 m soil layer in these plantations was 17.74, 5.14, 6.93, and 11.87 Mg C ha⁻¹, respectively, with SOC density decreasing with increasing soil depth. Total C storage in the plantation ecosystem averaged 26.57, 38.50, 69.78, and 79.79 Mg C ha⁻¹ in the 3, 6, 13 and 18- yrs plantation, with most of the C accumulated in the aboveground biomass rather than in the belowground root biomass and soil organic C. …”