G-protein coupled receptor kinase 2 (GRK2) regulates nuclear factor of activated T-cells (NFAT) nuclear activity via glycogen synthase kinase 3β (GSK3β). by Philipp Schlegel (588236)

“…<p>(A, B) G-protein coupled receptor (GPCR) induced nuclear NFAT activity is decreased by GRK2 knockdown. …”

Table_2_Disrupted metabolic signatures in amniotic fluid associated with increased risk of intestinal inflammation in cesarean section offspring.docx by Yongjie Liu (3166032)

Effects of Acute Exposure to Moderate Altitude on Vascular Function, Metabolism and Systemic Inflammation by Anne-Christin Stöwhas (440470)

Table_5_Disrupted metabolic signatures in amniotic fluid associated with increased risk of intestinal inflammation in cesarean section offspring.docx by Yongjie Liu (3166032)

Table_3_Disrupted metabolic signatures in amniotic fluid associated with increased risk of intestinal inflammation in cesarean section offspring.docx by Yongjie Liu (3166032)

Image3_miR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα.JPEG by Heming Ma (12357427)

Image2_miR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα.JPEG by Heming Ma (12357427)

Table_2_Intestinal Pioneer Colonizers as Drivers of Ileal Microbial Composition and Diversity of Broiler Chickens.xlsx by Denise R. Rodrigues (8270781)

The Implications of Relationships between Human Diseases and Metabolic Subpathways by Xia Li (14984)

USP RNAi screen reveals functions for USP4 and USP20 in granule neuron axon development. by Julius Anckar (685147)

Image2_Defining levels of care in cardiogenic shock.tiff by Miguel Alvarez Villela (17306389)

“…</p>Methods<p>Eleven of 23 hospitals within our healthcare system sharing a common electronic health record were classified as different LOC according to their highest mechanical circulatory support (MCS) capabilities: Level 1 (L-1)—durable left ventricular assist device, Level 1A (L-1A)—extracorporeal membrane oxygenation, Level 2 (L-2)—intra-aortic balloon pump and percutaneous ventricular assist device; and Level 3 (L-3)—no MCS. …”

Image3_Defining levels of care in cardiogenic shock.tiff by Miguel Alvarez Villela (17306389)

“…</p>Methods<p>Eleven of 23 hospitals within our healthcare system sharing a common electronic health record were classified as different LOC according to their highest mechanical circulatory support (MCS) capabilities: Level 1 (L-1)—durable left ventricular assist device, Level 1A (L-1A)—extracorporeal membrane oxygenation, Level 2 (L-2)—intra-aortic balloon pump and percutaneous ventricular assist device; and Level 3 (L-3)—no MCS. …”

Percentages of lipids present in serum per mouse plotted for quercetin mice to control mice. by Elise F. Hoek-van den Hil (286753)

“…Asterisks indicates a significant difference between the control and the quercetin group; * p<0.05, **p<0.01, *** p<0.001. …”

Humic Acid Composition and Characteristics of Soil Organic Matter in Relation to the Elevation Gradient of Moso Bamboo Plantations by Hsueh-Ching Wang (3095385)

The influences of smartphone use on the status of the tear film and ocular surface by Jung Han Choi (5917772)

“…Smartphone use showed significantly decreased FBUT and NIBUT at 4 h than those at baseline (<i>P</i> < 0.01). …”

p300 expression in melanoma patients. by Anand Rotte (464987)

“…(E) Percentage of strong cytoplasmic staining is significantly increased from nevi to melanoma by χ² test. **<i>P</i><.01, ***<i>P</i><.001.</p>…”

IL-10 treatment reduces mechanical allodynia and thermal hyperalgesia in HF mice. by Can Zhang (56016)

“…<p>A: IL-10 treatment decreased the degrees of mechanical allodynia in HF mice. …”

DYRK2 Negatively Regulates Cardiomyocyte Growth by Mediating Repressor Function of GSK-3β on eIF2Bε by Celine S. Weiss (453817)

“…</p><p>Results</p><p>(1) Under baseline conditions eIF2Bε transgenic mice showed no difference in cardiac phenotype compared to wild type, whereas in the mutant eIF2Bε-S⁵³⁵A an increase in LV/tibia length (7.5±0.4 mg/mm vs. 6.2±0.2 mg/mm, p<0.001) and cardiomyocyte cross sectional area (13004±570 vs. 10843±347 RU, p<0.01) was observed. (2) Cardiac overexpression of eIF2Bε did not change the response of the heart to pathologic stress induced by chronic isoproterenol treatment. (3) Cardiac overexpression of the eIF2Bε transgene was followed by overexpression of DYRK2 which is known to prime the inhibitory action of GSK-3β on eIF2Bε, while DYRK1A and GSK-3β itself were not increased. (4) In C57BL/6 mice after 48 h of isoproterenol-stimulation or aortic banding, eIF2Bε was increased and DYRK2 was concomitantly decreased. (5) In line with these in vivo findings, siRNA knockdown of DYRK2 in cultured cardiomyocytes resulted in decreased levels of p(S535)- eIF2Bε, (6) whereas adenoviral induced overexpression of DYRK2 was accompanied by clearly increased phosphorylation of eIF2Bε, indicating a coordinated response pattern (7) Adenoviral induced overexpression of DYRK2 leads to significantly reduced cardiomyocyte size and diminishes hypertrophic response to adrenergic stimulation.…”

Plasma Membrane Factor XIIIA Transglutaminase Activity Regulates Osteoblast Matrix Secretion and Deposition by Affecting Microtubule Dynamics by Hadil F. Al-Jallad (232597)

Image_2_Intra-Arterial Thrombolysis Vs. Mechanical Thrombectomy in Acute Minor Ischemic Stroke Due to Large Vessel Occlusion.TIF by Dapeng Sun (319496)

“…As compared to MT group, patients in the IAT alone group were associated with a higher chance of 90-day mRS 0-2 [93.7% vs. 71.9%, odds ratio (OR) = 4.75, 95% confidence interval (CI): 1.20–18.80, P = 0.027], a high chance of 90-day mRS 0-3 (96.8% vs. 86.7%, OR = 11.35, 95% CI: 1.93–66.86, P = 0.007), a shorter median time from puncture to recanalization (PTR) (60 min vs. 100 min, β = −63.70, 95% CI: −81.79– −45.61, P < 0.001), a lower chance of any intracranial hemorrhage (ICH) within 48 h (3.2% vs. 19.3%, OR = 0.15, 95% CI: 0.03–0.79, P = 0.025), and a lower chance of mortablity within 90 days (1.6% vs. 9.2%, OR = 0.05, 95% CI: 0.01–0.57, P = 0.016). …”