Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases by Xiao Li (107004)

“…CARM1 (coactivator-associated arginine methyltransferase 1), which belongs to type I PRMTs (protein arginine methyltransferases), is a potential therapeutic target for treatment of multiple cancers. In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC₅₀ = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC₅₀ = 18 ± 2 to 107 ± 6 nM). …”

Overexpression of Runx1 increases osteoblasts and decreases adipocytes and osteoblast markers levels <i>in vitro</i>. by Chen-Yi Tang (3619124)

Number of primary school classes, 2013−2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Primary school enrollment 2013−2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Number of primary schools, 2013–2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Decreased chromatin loops and CENH3 localizations in the CRM1 regions of the RNAi plants. by Yalin Liu (5341577)

Simulated decrease of cytokine concentration in the combined model. by Joonas P. Kosonen (14509643)

“…<p>(A) Simulated time-dependent exponential decrease of the interleukin-1 concentration in the culture medium and B) comparison of changes in proteoglycan (PG) content with constant (<i>μ</i> = 0 ) and fast-decreasing cytokine concentration (<i>μ</i> = 5.8×10⁻⁶ ). …”

Ecological subsections within CAKN parks with >0.1% surface water area overlaid with Alaska climate regions [29]. by Danielle L. Rupp (12889935)

Numerical results of for <i>R</i>_<i>d</i>, <i>Pr</i>, <i>γ</i>, <i>Ec</i> and <i>Du</i> when <i>Sr</i> = <i>Ha</i> = 0.1, <i>De</i> = 0.01, <i>Da</i> = <i>S</i> = <i>δ</... by Nur Azlina Mat Noor (10757590)

Outline of study visits. by Jordan K. Abbott (8934239)

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S18 Fig - by Jordan K. Abbott (8934239)

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S15 Fig - by Jordan K. Abbott (8934239)

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Proportions of intervals where cytokines change varies between cytokines. by Jordan K. Abbott (8934239)

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S2 Fig - by Jordan K. Abbott (8934239)

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S4 Fig - by Jordan K. Abbott (8934239)

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S14 Fig - by Jordan K. Abbott (8934239)

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Correlations of cytokines that significantly change between the pre-infusion and post-infusion blood draws pearson’s correlation between cytokine pairs is indicated by color and si... by Jordan K. Abbott (8934239)

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Statistically-significant cytokine changes between the pre-infusion and post-infusion blood draws plot of the mean (dot) and confidence interval (whiskers) for the coefficients of... by Jordan K. Abbott (8934239)

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S17 Fig - by Jordan K. Abbott (8934239)

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S9 Fig - by Jordan K. Abbott (8934239)

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