Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells by Yong-Chao Ma (174419)

“…Consistent with cellular apoptosis data, a significant decrease in topoisomerase IIβ activity was noted following treatment with HMNE3 for 24 h. …”

Fragmentation patterns for Schisandrin A. by Zhaoping Meng (4875040)

“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”

Chemical structure of a lignan. by Zhaoping Meng (4875040)

“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”

SIRT1 inhibition in dissociated E12.5 neocortical neurons enhanced SCPN/CSN subtype refinement, increasing the number of CTIP2-expressing, SATB2-negative neurons at the expense of... by Cameron Sadegh (11378606)

“…Data are presented as mean +/- s.e.m. (N = 3; >5,000 nuclei screened per condition from 40 randomly sampled fields at 20x magnification) *P < 0.05; **P < 0.01 (unpaired t-test).…”

DataSheet_1_Deciphering the causal association and co-disease mechanisms between psoriasis and breast cancer.pdf by Xujia Li (5912963)

“…Transcriptome analysis showed that CXCL13 and CCL20 were activated in both BC and psoriasis. Both diseases were also linked to neutrophil chemotaxis, the IL-17 pathway, and the chemokine pathway.…”

DataSheet_2_Deciphering the causal association and co-disease mechanisms between psoriasis and breast cancer.xlsx by Xujia Li (5912963)

“…Transcriptome analysis showed that CXCL13 and CCL20 were activated in both BC and psoriasis. Both diseases were also linked to neutrophil chemotaxis, the IL-17 pathway, and the chemokine pathway.…”

Table 2_Relationships between rumen methanogens and fungal communities and their response to changes in alfalfa forms and starch in sheep diets.xlsx by Wenliang Guo (14825407)

“…In this study, a 2 × 2 factorial design resulted in four diets: two alfalfa forms (AH and AS) and two RDS levels (LR: 14.85% DM RDS; and HR: 20.21% DM RDS). We used 32 female Suffolk sheep for the experiment. …”

Table 1_Relationships between rumen methanogens and fungal communities and their response to changes in alfalfa forms and starch in sheep diets.docx by Wenliang Guo (14825407)

“…In this study, a 2 × 2 factorial design resulted in four diets: two alfalfa forms (AH and AS) and two RDS levels (LR: 14.85% DM RDS; and HR: 20.21% DM RDS). We used 32 female Suffolk sheep for the experiment. …”

<b>Global patterns and drivers of soil dissolved organic carbon concentrations</b> by Andong Cai (10329365)

“…Elevation played the most important predictor for soil DOC prediction, followed by soil organic carbon, seasonal variability of temperature, and soil clay. Soil DOC decreases initially but increases when soil clay exceeds 20% and seasonal variability of temperature exceeds 0.7. …”

Table 1_Association between body composition in early pregnancy and the risk of gestational diabetes mellitus.docx by Yan Li (23143)

“…However, the association between body composition and GDM risk remains unclear. Therefore, we conducted a retrospective cohort study to investigate the relationship between body composition in early pregnancy and the risk of developing GDM.…”

Table_2_Tomato Rootstocks Mediate Plant-Water Relations and Leaf Nutrient Profiles of a Common Scion Under Suboptimal Soil Temperatures.DOCX by Steven T. Bristow (10013771)

“…BHN-589) to optimal (mean: 24°C) and SST (mean: 13.5°C) and compared their performance with the non-grafted BHN-589 cultivar. …”

Table_1_Tomato Rootstocks Mediate Plant-Water Relations and Leaf Nutrient Profiles of a Common Scion Under Suboptimal Soil Temperatures.DOCX by Steven T. Bristow (10013771)

“…BHN-589) to optimal (mean: 24°C) and SST (mean: 13.5°C) and compared their performance with the non-grafted BHN-589 cultivar. …”

Long-Term Effects of Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis: 3- and 6-Year Results of the ADJUVITE Trial by Yoo-Ri Chung (4231198)

“…Five years after the end of the trial, the mean BCVA improved to 0.07 ± 0.39 logMAR (vs. 0.14 ± 0.20 logMAR, <i>p</i> = 0.048) and the mean anterior chamber flare decreased to 29.9 ± 19.1 ph/ms (vs. 37.2 ± 35.0 ph/ms, <i>p</i> = 0.170). …”

The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines by Naohiko Matsushita (5105282)

“…The risk of post-rainfall leptospirosis peaked at a lag of 2 weeks (using 0 cm/week rainfall as the reference) with RRs of 1.30 (95% confidence interval: 0.99–1.70), 1.53 (1.12–2.09), 2.45 (1.80–3.33), 4.61 (3.30–6.43), and 13.77 (9.10–20.82) for light, moderate, heavy, intense and torrential rainfall (at 2, 5, 16, 32 and 63 cm/week), respectively. …”

Table_2_Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism.do... by Xiao-Chuan Li (3753502)

“…Based on the PPI analysis, the five most significant hub genes were PLK1, KIF20A, RRM2, CDC20, and UBE2C in the M1CM groups and RRM2, CCNB1, CDC20, PLK1, and UBE2C in the M2CM groups. …”

Table_3_Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism.do... by Xiao-Chuan Li (3753502)

“…Based on the PPI analysis, the five most significant hub genes were PLK1, KIF20A, RRM2, CDC20, and UBE2C in the M1CM groups and RRM2, CCNB1, CDC20, PLK1, and UBE2C in the M2CM groups. …”

Table_1_Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism.do... by Xiao-Chuan Li (3753502)

“…Based on the PPI analysis, the five most significant hub genes were PLK1, KIF20A, RRM2, CDC20, and UBE2C in the M1CM groups and RRM2, CCNB1, CDC20, PLK1, and UBE2C in the M2CM groups. …”

The GABBR1/miR-19b-3p/WNT2B axis regulates insulin resistance and liver injury in diabetes with viral infection: mechanistic and therapeutic insights by Rui Yang (293531)

Estrogen and Progesterone Regulate p27kip1 Levels via the Ubiquitin-Proteasome System: Pathogenic and Therapeutic Implications for Endometrial Cancer by Kuang-Tzu Huang (132734)

DataSheet1_Dihydroartemisinin Inhibits the Proliferation of Esophageal Squamous Cell Carcinoma Partially by Targeting AKT1 and p70S6K.pdf by Lili Zhu (219363)