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    Purified serum IgG from SPMS patients decreased the amount of claudin-5 protein, and IgG from all clinical subtypes of MS patients increased the amount of VCAM-1 protein in TY09 ce... by Fumitaka Shimizu (545145)

    Published 2014
    “…(E) The amount of claudin-5 protein in the TY09 cells was significantly decreased after exposure to the purified serum IgG fractions of SPMS patients, whereas it was not affected by the purified IgG fractions from RRMS-R or RRMS-S patients, or from healthy controls, as determined by a Western blot analysis. …”