Data_Sheet_1_Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy.PDF by Hannah Bergwell (16538259)

“…Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.</p>Methods<p>We began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80–47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08–49.40 years, Females = 27). …”

Genetic variance of a trait under stabilizing selection with multi-population demography. by Aaron P Ragsdale (20968248)

“…<p>(A,B) Two simple demographic models, in which Deme 1 has size 10,000 and Deme 2 has size 1,000. In each scenario, we allow 5<i>%</i> admixture from one deme to the other after begin isolated for 20,000 (2<i>N_e</i>) generations. …”

Identification of New Differentially Methylated Genes That Have Potential Functional Consequences in Prostate Cancer by Jin W. Kim (125178)

“…A total 28,735 CpG sites showed significant differences in DNA methylation (FDR adjusted <em>P</em><0.05), defined as a mean methylation difference of at least 20% between PCa and normal samples. Furthermore, a total of 122 genes had more than one differentially methylated CpG site in their promoter region and a gene expression pattern that was inverse to the direction of change in DNA methylation (e.g. decreased expression with increased methylation, and vice-versa). …”

Image 3_EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway.tif by Xiaoying Huang (328697)

“…Moreover, a relationship between EPHA2, pyroptosis, and the AKT/PI3K pathway was established and confirmed. Additionally, we observed a decreased expression of ferroptosis-associated marker named SLC7A11, suggesting that this transporter may mediate the effects of AKT inhibition on pyroptosis.…”

Table_3_Conservation Genomics of the Declining North American Bumblebee Bombus terricola Reveals Inbreeding and Selection on Immune Genes.xlsx by Clement F. Kent (260706)

“…Second, we sequenced the individual genomes of 22 bumblebee gynes from Ontario and Quebec using Illumina HiSeq 2500, each at an average depth of 20×, which were used to improve the PacBio genome calls and for population genetic analyses. …”

Table_1_Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease.pdf by Xiaodong Yang (158369)

“…<p>Decreased expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is implicated in the pathophysiology of Parkinson’s disease (PD). …”

Table_1_Conservation Genomics of the Declining North American Bumblebee Bombus terricola Reveals Inbreeding and Selection on Immune Genes.DOCX by Clement F. Kent (260706)

“…Second, we sequenced the individual genomes of 22 bumblebee gynes from Ontario and Quebec using Illumina HiSeq 2500, each at an average depth of 20×, which were used to improve the PacBio genome calls and for population genetic analyses. …”

Table_2_Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic... by Yi-Tung Chen (6743102)

“…Herein, we comprehensively profile 103 peripheral blood samples from 20 healthy controls and 16 CRC patients with a follow-up of 98 to 452 days to identify hypervariable rearrangements of the TCRα and TCRβ repertoires using high-throughput sequencing. …”

Vascular and Inflammatory High Fat Meal Responses in Young Healthy Men; A Discriminative Role of IL-8 Observed in a Randomized Trial by Diederik Esser (148846)

“…</p> <h3>Methods</h3><p>In a double-blind randomized cross-over intervention study, we used a comprehensive phenotyping approach to determine the vascular and inflammatory response after consumption of a high fat shake and after an average breakfast shake in 20 young healthy subjects. …”

Table_1_The Lotus japonicus ROP3 Is Involved in the Establishment of the Nitrogen-Fixing Symbiosis but Not of the Arbuscular Mycorrhizal Symbiosis.DOCX by Ivette García-Soto (11684935)

“…Moreover, we evaluated the expression of key genes related to CSSP and to the rhizobial-specific pathway. …”

Image1_Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates.TIF by Myung-Eui Seo (6822518)

“…The five variants with decreased metabolic capability (<50%) of wild type for either substrates were evaluated as protein damaging by all three in silico prediction algorithms, except CADD exact score of NM_000769.4:c.593T>C that was 19.68 (<20.0). …”

Data_Sheet_1_The Lotus japonicus ROP3 Is Involved in the Establishment of the Nitrogen-Fixing Symbiosis but Not of the Arbuscular Mycorrhizal Symbiosis.PDF by Ivette García-Soto (11684935)

“…Moreover, we evaluated the expression of key genes related to CSSP and to the rhizobial-specific pathway. …”

Perfusion Network Shift during Seizures in Medial Temporal Lobe Epilepsy by Karen M. Sequeira (103850)

“…</p> <h3>Methods</h3><p>We studied clinical information and single photon emission computed tomography (SPECT) images obtained with intravenous infusion of the radioactive tracer Technetium- Tc 99 m Hexamethylpropyleneamine Oxime (Tc-99 m HMPAO) during ictal and interictal state confirmed by video-electroencephalography (VEEG) in 20 patients with unilateral MTLE (12 left and 8 right MTLE). …”

Image2_Association between body fat distribution and age at menarche: a two sample Mendelian randomization study.pdf by Peng Xue (219948)

“…After Bonferroni correction, we found that whole body fat mass (β: −0.17; 95% CI: −0.24, −0.11), left leg fat percentage (β: −0.14; 95% CI: −0.21, −0.07), left leg fat mass (β: −0.20; 95% CI: −0.27, −0.12), left arm fat percentage (β: −0.18; 95% CI: −0.26, −0.11) and left arm fat mass (β: −0.18; 95%CI: −0.26, −0.10) were associated with decreased AAM using random effects IVW method. …”

Monte Carlo simulations of microtubule arrays: The critical roles of rescue transitions, the cell boundary, and tubulin concentration in shaping microtubule distributions by Lynne Cassimeris (91340)

“…Using this platform and reported parameters measured in interphase LLCPK1 epithelial cells, we predict that sequestering ~ 15–20% of total tubulin results in fewer microtubules, but promotes dynamic instability of those remaining. …”

Image_1_Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.PDF by Masatsugu Ohara (5511236)

“…Beginning at 3 weeks, PEA (20 mg/kg) was intraperitoneally injected thrice a week for 2 weeks. …”

Image1_In the fed state, autophagy plays a crucial role in assisting the insect vector Rhodnius prolixus mobilize TAG reserves under forced flight activity.pdf by Samara Santos-Araujo (12841922)

“…Herein, because it is known that autophagy can be modulated in response to various stimuli, we further investigated the role of autophagy in the fed state, following blood feeding. …”

Data_Sheet_1_Climate Change and Management Impacts on Soybean N Fixation, Soil N Mineralization, N2O Emissions, and Seed Yield.docx by Elvis F. Elli (8707077)

“…Climate change (2020–2080) increased N mineralization (24%) and N₂O emissions (19%) but decreased N fixation (32%), seed N (20%), and yields (19%). …”

Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice by Shankar Sadasivan (176192)

“…</p> <h3>Methodology/Principal Findings</h3><p>Through the use of stereological counting methods, we observed a significant reduction (∼20%) in dopamine neuron numbers in the substantia nigra pars compacta (SNpc) following chronic administration of 10 mg/kg MPH. …”

Table_4_Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic... by Yi-Tung Chen (6743102)

“…Herein, we comprehensively profile 103 peripheral blood samples from 20 healthy controls and 16 CRC patients with a follow-up of 98 to 452 days to identify hypervariable rearrangements of the TCRα and TCRβ repertoires using high-throughput sequencing. …”