Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

“…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …”

Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

“…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC₅₀ at 2.1 μM. …”

Chemical Analysis and Antidiabetic Potential of a Decoction from <i>Stevia serrata</i> Roots by Sofía Padilla-Mayne (17027483)

“…Compounds <b>1</b>–<b>5</b> were tested also against PTP1B_1–400 and showed IC₅₀ values of 1180.9 ± 0.33, 526.8 ± 0.02, 532.1 ± 0.03, 928.2 ± 0.39, and 31.8 ± 1.09 μM, respectively. …”

Intravenous treatment of naïve wild-type mice with PrP LSPCs decreased PrP^C mRNA and cell surface PrP^C protein at various time points. by Heather Bender (363996)

Results for fibrin dominant clots: (A) time to recanalize <i>in vitro</i> model; (B) relative clot reduction; (C) RBC release; (D) relative clot degradation rate. by Sandra Thalerová (11434762)

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Transparent <i>in vitro</i> MCA model preparation. by Sandra Thalerová (11434762)

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Complete data. by Sandra Thalerová (11434762)

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Proposed concept of collaterals action: The collateral circulation lowered the pressure across the clot which resulted in lesser clot compaction and a subsequent easier clot distal... by Sandra Thalerová (11434762)

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Initial RBC dominant clot compaction in the <i>in vitro</i> MCA model without and with collateral with alteplase applied at clinically relevant concentration (1.3 mg L^-1... by Sandra Thalerová (11434762)

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Video of real-time recanalization of <i>in vitro</i> MCA model. by Sandra Thalerová (11434762)

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Detailed representation of <i>in vitro</i> MCA model dimensions. by Sandra Thalerová (11434762)

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Video of <i>in vitro</i> MCA model occlusion with RBC dominant clot. by Sandra Thalerová (11434762)

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Histological analysis of <i>in vitro</i> blood clots. by Sandra Thalerová (11434762)

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Results for RBC dominant clots: (A) time to recanalize <i>in vitro</i> model; (B) relative clot reduction; (C) RBC release; (D) relative clot degradation rate. by Sandra Thalerová (11434762)

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Experiment course scheme. by Sandra Thalerová (11434762)

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Schematic of <i>in vitro</i> MCA model set-up. by Sandra Thalerová (11434762)

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Protective effect and mechanism of low P50 haemoglobin oxygen carrier on isolated rat heart by Wentao Zhou (5867126)

“…However, the oxygen-carrying and releasing capacity (P50) is different with different HBOCs. The aim of our study was to investigate whether STS (a kind of cardioprotective solution, St Thomas Solution) +different P50 HBOCs provide superior myocardial protection and decrease myocardial injury compared to only STS in rats Langendorff isolated heart perfusion model. …”

Shapefiles of canopy disturbances for the 50-ha plot on Barro Colorado Island, Panama, for 2014-2019 by Raquel F. Araujo (10648181)

“…We defined a canopy disturbance as a substantial decrease in canopy height in a contiguous patch of canopy occurring over one measurement interval. …”

Effects of decreasing minor allele frequency under H₀. by Veronica J. Vieland (8796587)

Velocity distribution at different openings (a) 25%; (b) 50%; (c) 75%; (d) 100%. by Weiqing Xu (1279959)