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A decrease in cellular RNA increases the insolubility of TDP-43.
Published 2013“…(C) Immunoblots of the immunoprecipitated protein with anti-V5 antibody or control IgG. (D) Reverse transcription-PCR (RT-PCR) of hNFL from immunoprecipitated RNA. …”
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Downregulation of DOM decreases the abundance of PER and TIM.
Published 2019“…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …”
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Classification of genes whose expression was decreased after removal of SOX9.
Published 2014“…Genes whose expression was decreased by more than 6-fold by the removal of SOX9 were classified into 20 functional groups; the percentages in each group of more than five genes containing a SOX9-interaction site revealed by ChIP-Seq are underlined in red on the left: the first percentage is for mouse rib chondrocytes and the second for RCS cells. …”
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Mesothelin expression and RG7787 uptake is decreased in KLM-1-R.
Published 2015“…<p><b>A</b>: Surface mesothelin levels are 5-fold lower in resistant KLM-1 (KLM-1-R) compared to KLM-1. …”
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LiCl administered via 0.5% LiCl food pellets for 4 wks decreases the antioxidant stress response.
Published 2015“…<p>(A) LiCl decreases <i>Nrf2</i> transcripts in hippocampus and cortex of R236H/+ mice (N = 5 male mice per group). …”
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Mitochondrial dysfunction is driven by decreased mitochondrial dynamics.
Published 2014“…<p>(A) Sensitivity analysis averaged along the time course for the mitochondrial species in the model by varying the mitochondrial-related kinetic rate constant parameters. …”
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…<b>(B)</b> Representative data show total membrane current, the time courses of [Na<sup>+</sup>]<sub>e</sub>, [Glu<sup>-</sup>]<sub>e</sub>, and [DHK]<sub>e</sub> at the top, and HP voltage ramps (–100 to +20 mV) at the bottom. Arrow head points to simultaneous decrease in [Glu<sup>-</sup>]<sub>e</sub> and [Na<sup>+</sup>]<sub>e</sub>, which affects the current. …”
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Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Published 2013“…Six microRNAs (miR-155, miR-454, miR-582-5p, let-7f-1*, miR-181d, and miR-500) had >1.2-fold increase in cirrhotic livers and also had significant negative correlation with hepatic CYP3A activity (range of r = -0.44 to -0.52, P <0.05). …”
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VRK1 overexpression is seen in human breast cancer and is associated with decreased relapse-free survival.
Published 2018“…Data for cancer subtypes are shown in boxes numbered 1–11: 1: benign breast neoplasm (rank 6459, 1.4 fold-change, NS), 2: breast carcinoma (rank 833, 1.5 fold-change, p = 3.83x10<sup>-5</sup>), 3: breast phyllodes tumor (rank 512, 1.2 fold-change, p = 0.002), 4: ductal breast carcinoma in situ (rank 1969, 1.5 fold-change, p = 0.002), 5: invasive breast carcinoma (rank 1060, 1.6 fold-change, p = 1.28x10<sup>-5</sup>), 6: invasive ductal and invasive lobular breast carcinoma (rank 941, 1.5 fold-change, p = 6.76x10<sup>-22</sup>), 7: invasive ductal breast carcinoma (rank 613, 1.5-fold change, p = 2.71x10<sup>-71</sup>), 8: invasive lobular breast carcinoma (rank 947, 1.3 fold-change, p = 3.64x10<sup>-28</sup>), 9: medullary breast carcinoma (rank 400, 1.8 fold-change, p = 3.25x10<sup>-12</sup>), 10: mucinous breast carcinoma (rank 1932, 1.4 fold-change, p = 7.41x10<sup>-10</sup>) and 11: tubular breast carcinoma (rank 1253, 1.4 fold-change, p = 1.24x10<sup>-17</sup>). …”
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PowerPoint Slides for: Patiromer Decreases Serum Potassium and Phosphate Levels in Patients on Hemodialysis
Published 2016“…<p><b><i>Background:</i></b> Persistent hyperkalemia (serum potassium (K) ≥5.5 mEq/l) is a common condition in hemodialysis (HD) patients, is associated with increased mortality, and treatment options are limited. …”