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09 0 » 0 0 (Expand Search), 01 0 (Expand Search), 05 0 (Expand Search)
ns decrease » _ decrease (Expand Search), a decrease (Expand Search), use decreased (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
0 decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
09 0 » 0 0 (Expand Search), 01 0 (Expand Search), 05 0 (Expand Search)
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First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation
Published 2022“…In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which displays superior pharmacokinetic properties to the current hydroxamic acid inhibitors. …”
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First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation
Published 2022“…In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which displays superior pharmacokinetic properties to the current hydroxamic acid inhibitors. …”
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376
Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer
Published 2023“…Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity. …”
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377
SEM image of the B0P0 mixture.
Published 2025“…The results indicate that the optimal combination was 0.1% volume content of 12-mm-long basalt fibers and 1.0% mass content of polycarboxylate superplasticizer, which yielded a compressive strength of 13.3 MPa and a splitting tensile strength of 1.14 MPa at 28 days. …”
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Histopathological lesions of the spleen in Afg09-2990 and Hoti infected WT mice on day 4.
Published 2022“…H&E staining showing depletion of lymphocytes in the white pulp and increased cell density in the red pulp of Afg09-2990 infected mice. Neutrophilic inflammation in the red pulp (black arrows), increased cell density in the red pulp due to histiocytes infiltration and decreased cellularity of the white pulp with tingible body macrophages (lymphocyte apoptosis) was seen in both groups. …”