Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

Madrasin decreases transcription of protein-coding genes. by Michael Tellier (8284752)

Magnitude of compressive residual stresses versus the <i>t/h</i>_<i>0</i>. by Yihan Tu (22258445)

Average of % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.... by Indrani Bera (804948)

Maximum body temperature decrease within eight hours after administration of dipyrone, acetaminophen or no medication. by Hans-Jörg Gillmann (8460585)

Subjects:

A sample precision curve of "anogenital sniffing" classifier shows its maximum F1 = 0.77 at Detection Threshold ~ 0.3. by Piotr Popik (292215)

DataSheet_1_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.zip by Xiao-yang Gong (13103400)

“…Background<p>Patients with early-stage laryngeal cancer, even stage T1-2N0, are at considerable risk of recurrence and death. …”

Temperature below the ceiling of the cable compartment in utility tunnel at 7 and 8 at a distance of -1.0 m and -2.0 m from the fire source. by Z. P. Bai (8052827)

Shares of specialist groups prescribing 1^st, 2^nd, and 3^rd antibiotic prescriptions in UTI treatment of females (N39.0, N30.0) in 2018 and 2019. by Thomas Hanslmeier (19949694)

S1 Data - by Elizabeth Dufourcq Sekatcheff (17457627)

“…To go further, we used the same experimental design to assess more precisely the molecular determinants of reproductive toxicity, primarily decreases in gamete number. …”

Alpha diversity in F2 samples with sulfite treatment at time 0. by Sally V. Irwin (4521733)

Example of calculating the area under the threshold of the serum albumin curve up to postoperative day 5 (preset threshold = 3.0 g/dL). by Yoonjee Cho (15453454)

Consumer surplus in different scenarios (<i>α</i> = 0.075). by Ying Shi (115282)

R(lag-1) values for serial correlation test (limits are 0.28 and -0.28). by Asnake Adane (19935018)

Antibiotics decrease microbiota α-diversity. by Caroline A. McKinney (8555676)

S1 Dataset - by Jana Butzmann (18966537)

“…In group I 48/48 (100.0%; 95% CI 92.6% to 100.0%), in group II 93/96 (96.9%; 95% CI 91.2% to 98.9%) and in group III 209/210 (99.5%; 95% CI 97.4% to 99.9%) self-tests were carried out at home. …”

Average % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.01,... by Indrani Bera (804948)

Average of % peptides counts for different classes of proteins at different germination time points and significant p-value indicated as compared to soaked sample (*p< 0.05, **p<0.... by Indrani Bera (804948)

Duration in days (mean ±  SE) of the egg, nymphal instars, total nymphal development, adult longevity, percentage of nymphal mortality, and sex ratio (proportion of females) of <i>... by Gonçalo Abraços-Duarte (21030010)

Shares of antibiotic substances on total prescription by quarter from 2013 to 2019 for female and male patients with UTI (N39.0, N30.0)(female: n = 1.681.255 prescriptions; male: n... by Thomas Hanslmeier (19949694)