Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Table_1_Trends and Disparities in the Incidence of Intraocular Foreign Bodies 1990–2019: A Global Analysis.DOCX by Minjie Yuan (11568097)

“…</p>Results<p>Globally, although ASIR of IOFBs decreased with an EAPC of −0.93% [95% uncertainty interval (UI) −1.1 to −0.76] from 1990 to 2019, ASIR of IOFBs increased from 2008 to 2019. …”

Functional connectivity changes in the PAIN compared to the REST (PAIN-REST) in the LBP patients and the HC (cluster-corrected for multiple comparisons, Z > 2.3 and P < 0.05). by Seulgi Eun (6238004)

Calculation of peak force and impulse values from trial with overlap. by Leena Inkilä (20614460)

Antibodies used for western blot. by Chenyi Xia (11283023)

“…Administration of GBE50 regulated the activities of these three enzymes and induced a decrease in H₂O₂. …”

Table_1_Family psychoeducation to improve outcome in caregivers and patients with schizophrenia: a randomized clinical trial.docx by Arnaud Tessier (1734355)

“…On the 25 caregivers included, the mean age was 50.6 years (SD = 14.0). Twenty-one were female (84.0%), 12 were married (48.0%) and 11 lived alone (44.0%). …”

Data Sheet 1_Safety and immunomodulatory efficacy of heat-killed Mycolicibacterium manresensis as a novel paraprobiotic in swine.pdf by Carmen Álvarez-Delgado (18964264)

“…For this purpose, twenty-four-week-old piglets, were assigned to four experimental groups, and the diet of three of them was supplemented with 10, 50 and 100 ppm of hkMm, respectively, during a period of 70 d. …”

Microwave ablation combined with anti-PD-1/CTLA-4 therapy induces an antitumor immune response to renal cell carcinoma in a murine model by Run-Qi Guo (13266491)

“…MWA treatment increased PD-L1/PD-1 expression; however, after the combination treatment with ICI, PD-L1/PD-1 expression was decreased. According to the rechallenge test, mice (16.7%) in the MWA group, ICI group (50%), and MWA+ICI group (66.7%) exhibited successful tumor rejection, whereas no mice in the control group exhibited the capability of tumor rejection. …”

Microtumors exhibit physiological responses to paclitaxel or fluorouracil treatment, and microtumors exhibit a decrease in breast cancer cell proliferation compared to 2D and 3D mo... by Gabriel Benton (719539)

Table_1_Ideal Cardiovascular Health in Young Adults With Established Cardiovascular Diseases.DOCX by Jane A. Leopold (12098417)

“…Young adults with cardiovascular disease (n = 349) were older, had a lower socioeconomic status, a higher prevalence of risk factors, and lower Life's Simple 7 Health Scores (6.4 ± 1.5 vs. 7.1 ± 1.5, p < 0.01) compared to young adults without cardiovascular disease (n = 696). …”

Time (in seconds) spent by each participant per case. by Michelle Noga (3637138)

Errors in identifying PVS and localization of veins for monoscopic and stereoscopic images. by Michelle Noga (3637138)

Viewing order distribution of 4 test sets among the 2 participant groups. by Michelle Noga (3637138)

Distribution of cases into test sets. by Michelle Noga (3637138)