Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling by Chung, Jihyun

“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Biomolecular alterations in acute traumatic brain injury (TBI) using Fourier transform infrared (FTIR) imaging spectroscopy by Rakib, Fazle

“…Acute injury is one of the substantial stage post-traumatic brain injury (TBI) occurring at the moment of impact. …”
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Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials. by Wanas, Yara

“…The pooled estimates revealed that ARBs do not increase the risk of all-cause mortality (RR 1.00; 95%CI 0.97-1.04), myocardial infarction (RR 1.01; 95%CI 0.96-1.06), and stroke (RR 0.92; 95%CI 0.83-1.01). …”
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Antiferromagnetism in EuPdGe3 by Albedah, M.A.

“…EuPdGe3 crystallizes in the BaNiSn3-type tetragonal structure (space group I4mm) with the lattice constants a=4.4457(1)Å and c=10.1703(2)Å. …”
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Association between Serum Vitamin D Status and Circadian Syndrome: A Cross-Sectional Study by Arabi, Ahmed

“…Results: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. …”
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An Overview of Solid Waste Management and Plastic Recycling in Qatar by Al-Maaded, M.

“…Municipal solid waste management (MSWM) constitutes one of the most crucial health and environmental problems facing authorities in the Arabian Gulf. …”
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Comparison of fosfomycin against fluoroquinolones for transrectal prostate biopsy prophylaxis: an individual patient-data meta-analysis by Roberts M.J.

“…The number needed to treat with TAP to avoid one more infection when compared to the EAP group was 39. …”
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Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly by Zakaria, El Rasheid

“…We made an incidental observation of decreased PDS-induced, NO-dependent peritoneal microvascular vasoreactivity in elderly rats nave to PDS exposure. …”
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A new insight into the separation of oil from oil/water emulsion by Fe3O4?SiO2 nanoparticles by Elmobarak W.F.

“…For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. …”
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Dietary patterns associated with the risk of pancreatic cancer: Case-control study findings by Tayyem, Reema

“…The "Traditional"dietary pattern, which presented a diet rich in fresh fruits, vegetables, milk, yogurt, and lentils, was associated with a significant decrease in the odds of PC (OR = 0.42, 95% CI = 0.21-0.84) for the third quartile compared to first one. …”
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Molecular and Peritoneal Microvascular Changes Cause Peritoneal Membrane Dysfunction by Uremia-Related Mechanisms by Zakaria, El-Rasheid

“…Three animal groups were used: Group - I: Chronic PD solution infusion: Interventions included indwelling peritoneal catheter placement and daily infusion of a glucose-based clinical PD solution for one month. …”
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Responses of lichen communities to 18 years of natural and experimental warming by Alatalo, Juha M.

“…The negative effect on species richness and effective number of species was driven by a decrease in lichens under experimental warming in the meadow. …”
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Utilization of Two Microalgae Species, Synechococcus sp. and Cheatoceros sp., for Aquatic Toxicity Assessments in the Qatari Marine Environmen by Bacha, Sarah

“…The lowest growth rates were observed at the lowest temperatures, while a decreased rate was also observed at the highest temperature. …”
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The influence of aeration scheme and aeration rate on the permeate flux for wastewater treatment using membrane bioreactors: Experimental and artificial neural network modeling by Jawad, Jasir

“…The average normalized flux decreased as the MLSS concentration increased from 5 to 15 g/L and increased as the aeration rate increased from 0.5 to 1.5 LPM. …”
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Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inf... by Rabbani, Naila

“…Changes in CCL2, IL-8, and RAGE were intercorrelated and all correlated positively with changes in MLXIP, MAFF, MAFG, NCF1, and FTH1, and negatively with changes in HMOX1 and TKT; changes in IL-8 also correlated positively with change in COX-2. …”
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Development of Internally Pressurized Composite/Metallic/Composite Hybrid Pipes by Alabtah, Fatima Ghassan

“…To this end, fracture loads for modes I and II were experimentally determined for FRP/steel samples with different fiber types and orientations. …”
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Muscle-damaging exercise 48 h prior to a maximal incremental exercise treadmill test reduces time to exhaustion: is it time to reconsider our pretest procedures? by Chrismas, Bryna Catherine Rose

“…From MIEEXP2 to MIEEXP3 average time to exhaustion (TTE) decreased by 45 s (9%) (p < 0.01), maximum blood lactate decreased by 1.2 mmol/L (11%) (p = 0.03), and perceived readiness decreased by 8 mm (18%) (p = 0.01). …”
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Static fracture and modal analysis simulation of a gas turbine compressor blade and bladed disk system by Fernandes, Ralston

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Enhancing compressive, tensile, thermal and damping response of pure Al using BN nanoparticles by Penchal Reddy M.

“…In the present study, aluminum based metal matrix composites containing various amounts of boron nitride (BN) nanoparticulates (0, 0.5, 1.0 and 1.5 vol.%) were fabricated by using the powder metallurgy (PM) technique involving microwave sintering and hot extrusion process. …”
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Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021 by Austin, Carter

“…HIV-related deaths decreased by 39·7% (33·7–44·5), from 1·19 million (1·07–1·37) in 2010 to 718 000 (669 000–785 000) in 2021. …”
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