CD8 stimulation induces M1 phenotype. by Jan Boddaert (4775013)

“…<p>(<b>A</b>) Left panel shows increased iNOS+ and decreased Arg1+ staining in cultured peripheral macrophages after 24h with CD8-stimulating ligand, compared to the IgG1 isotype control. …”

Mortality dataset used in analysis. by Samuel Sendagala (21417164)

Subjects:

Kaplan-Meier survival curves according to H1x (A, B): nuclear SUV39H1 (C, D) and cytoplasmic SUV39H1 (E) in the entire cohort (A, B, C) as well as in glioblastomas (B, D) in the pa... by Athanasia Sepsa (684773)

“…<p>Increased H1x, increased nuclear SUV39H1 and decreased cytoplasmic SUV39H1 expression were associated with improved overall survival.…”

miR-335-3p targeting THBS1 is downregulated in the fibrosis model. by Dong-Hee Han (140305)

“…<b>(C)</b> The expression of miR-335-3p decreased after TGF-β1 treatment in both cell lines. …”

mTORC1 inhibits Runx2 expression by activating Notch signaling in preosteoblasts. by Bin Huang (331329)

“…<p>(A) Control (C) and Δ<i>Tsc1</i> (Δ) primary calvarial cells were treated with vehicle (V) or 0.1 nM rapamycin (R) for 24 hours and then underwent immunoblotting to detect Runx2. …”

Key biological processes and genes are identified in TGF-β1-induced fibrosis via transcriptome analysis. by Dong-Hee Han (140305)

“…<b>(D, E)</b> Protein–protein interaction was analyzed on the 48 selected DEGs; red and blue represented the increased and decreased expression levels, respectively, in response to TGF-β1 treatment. …”

FTH1P3 enhanced the uveal melanoma cell proliferation and migration by inhibiting the miR-224-5p expression. by Xiaoli Zheng (232806)

“…(E) Overexpression of miR-224-5p decreased the cell cycle in the FTH1P3 overexpressing-MUM-2B cell. …”

Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement by Frédéric Canini (5309426)

“…In C+CN rats, stress induced an increase in <i>Pten</i> but a decrease in <i>Gys1</i> mRNA expression. …”

mRNA expression of Il-8 and mRNA and protein expression of TRPV1 in the ileum and colon of never and currently smoking healthy subjects and Crohn’s Disease (CD) patients. by Liesbeth Allais (820751)

“…(D) Expression of <i>Trpv1</i> mRNA in the colon decreased in active smoking healthy subjects compared to never smoking healthy subjects. …”

SAHA specifically down regulates <i>Hdac7</i> mRNA levels. by Caroline L. Benn (195214)

“…(A) <i>Hdac7</i> mRNA expression levels are shown as relative expression ratios to the geometric mean of the <i>Actb</i> and <i>Grin1</i> housekeeping genes in 13 week old mouse cerebellum from SAHA-treated WT (grey) and R6/2 (black) mice together with vehicle treated WT (white) and R6/2 (striped) mice (n>8 per genotype). …”

Expression analyses of the AdeIJK and MacAB-TolC pump genes in the laboratory-induced and clinical tigecycline-resistant <i>A. baumannii</i> and their <i>baeR</i> mutant strains. by Ming-Feng Lin (768243)

“…(B) The expression levels of <i>adeI</i>, <i>adeJ</i>, and <i>adeK</i> in ABhl1 exhibited a statistically significant decrease compared with the wild-type strain, whereas the expression levels of <i>tolC</i> and <i>macB</i> increased 1.7 and 2.3-fold, respectively. …”

Effect of ABPP on the neuronal density in the CA1 region of hippocampus. by Hongmei Shen (382343)

“…Neuronal density taken by a representative rat from each group at 30^th day after MCAO (C-I; bar, 50 µm). …”

Na_v1.7 controls action potential threshold and contributes to the rising phase. by Aristos J. Alexandrou (2601481)

“…Phase plot of the action potential depicted in <i>B</i>. D. PF-05198007 depolarized the action potential voltage threshold and decreased both the peak amplitude and upstroke slope (n = 7 neurons, * p < 0.05, ** p < 0.01, paired t-test, data shown ±SEM). …”

Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia by Toshiki Hirakawa (413449)

“…The motility-stimulating ability of CAFs was decreased by IGF1R inhibitors. These findings might suggest that pancreas CAFs stimulate the invasion activity of PDAC cells through paracrine IGF1/IGF1R signaling, especially under hypoxia. …”

Inhibition of GST-<i>Pf</i>ACβ_1-785 by KH7, KH7.15, and 2-CE. by Eric Salazar (55919)

“…The level of untreated activity was lower in methanol (2-CE vehicle)-treated samples. (C) Activity in <i>Pf</i>ACα-expressing Hi5 cells was assayed in the presence of 50 µM KH7, 1 mM KH7.15, and 50 µM 2-CE. …”

Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate <i>de novo</i> Assembly of Heterochromatin by Michelle L. Larin (2205109)

“…<i>De novo</i> assembly cannot occur in the G1 phase of the cell cycle and one to two divisions are needed for complete silent chromatin assembly and transcriptional repression. …”

GDM-Induced Macrosomia Is Reversed by Cav-1 via AMPK-Mediated Fatty Acid Transport and GLUT1-Mediated Glucose Transport in Placenta by Guo Yao (3709834)

“…</p><p>Results</p><p>In the GDMM placenta group, both protein and mRNA levels of Cav-1 were down-regulated, while GLUT1 was up-regulated; the phosphorylation and mRNA levels of ACC and AMPKα were decreased, but total ACC protein levels were increased compared to both the GDMN (p<0.05) and CON groups (p<0.05). …”

Study of KERP1 involvement in trophozoite interaction with LSECs. by Carlos F. Solis (255470)

“…Quantification of trophozoites bound to LSECs after 30 min contact showed 50% decrease in adherence of KERP1-reduced trophozoites. …”

Effect of a coordinated reduction in multiple enzymes on sterol biosynthesis. by Mathieu Blanc (139647)

“…Infection was measured by detection of the IE1 mCMV antigen. Intensity values relative to β-actin calculated by densitometry show a decrease of the total amount of protein in the mCMV-infected BMDM compared to the mock-treated samples of 64% for HMGCS1, 50% for HMGCR, and 85% for SQLE. …”

Adoptive transfer of wild-type macrophages reduces lung fibrosis in myFoxm1^-/- mice. by Chinmayee Goda (8694597)

“…<p><b>(A)</b> Overexpression of <i>Dusp1</i> decreases expression of <i>Tnf</i>, <i>Il6</i> and <i>Il1b</i> in FOXM1-deficient macrophages. …”