Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation حسب El Hasasna, Hussain

"…Furthermore, we found that while both autophagy inhibitors abolished p38 phosphorylation, only CQ led to significant decrease in pERK1/2. Finally, RCE induced DNA damage and reduced mutant p53, two events that preceded autophagy. …"
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Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia حسب Kuttikrishnan S.

"…The cytochrome c then mediates the activation of caspase-cascade and subsequently PARP cleavage. Furthermore, pretreatment with z-VAD-FMK, a pan-caspase inhibitor, abrogated Sang-induced inhibition of cell viability, induction of apoptosis. …"
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. حسب Akhtar, Sabah

"…In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. …"
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Novel Isosteviol Derivatives Induced Apoptosis In Human Lung Cancer حسب Malki, Ahmed

"…Both isosteviol derivatives 8c and 9d increased Caspase 3 activities and induced Parp-1 cleavage in H1299 cells. Both derivative 8c and 9d reduced expression levels of AKT and Bcl-2 and increased expression levels of Bax and Bad in H1299cells. …"
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Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents حسب Ayoub, Abeer J.

"…Inhibition of the expression of the antiapoptotic protein Bcl-2 and concentration-dependent cleavage of PARP-1, as well as DNA fragmentation by approximately 80%, were described. …"
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Anticancer activity of Neosetophomone B, A Fungal Secondary Metabolite, against Hematological Malignancies حسب Kuttikrishnan, Shilpa

"…Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. …"
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