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681
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…MYBPC3 variants genotype–phenotype associations remain poorly understood. We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
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682
Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III.
Published 2023“…Decreases in mean splenic length were observed, whereas the liver volume did not change. …”
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683
Comparison Of In Vitro Models Of Diabetic Nephropathy Using Renal Tubular Cells
Published 2014“…Results: MDCK cells showed a subtle decrease in viability when exposed to high glucose concentrations (30 mM and 1% FBS) for 48 h. …”
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684
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
Published 2021“…These effects were counteracted by AM630 co-incubation, thus confirming that BCP’s mechanism of action is mainly related to CB2R modulation. A decrease in β-catenin regulated the impaired cell cycle and especially promoted cyclin D1 and CDK 4/6 reduction. …”
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685
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686
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687
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688
Integrated planning of spare parts and service engineers with partial backlogging
Published 2017“…In a numerical study, we show that for problems with more than five types of spare parts it is preferable to use approximate evaluations as they become significantly faster than exact evaluation. …”
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689
Detoxification assays of tunisian tannery wastewater under nonsterile conditions using the filamentous fungus aspergillus Niger
Published 2019“…Characterization of effluents also revealed high salt levels (EC > 17 mS/cm) and high organic matter content (25 g/L for the UE and 7.2 g/L for the FE) but a low biodegradability since BOD5 did not exceed 2.5 and 1.25 g/L for the UE and the FE, respectively. …”
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690
Symbiotic dinoflagellates associated with corals in Qatar: characterization and physiological response to environmental change
Published 2017“…Coral bleaching events witnessed during the last decades in the Arabian Gulf are believed to be the result of the effect of heat events occurring more frequently in the region as a result of the global ocean warming. When corals are under thermal stress, their symbiotic zooxanthellae are affected, and their photosynthetic activity decreases until the stress disappears or until the zooxanthellae are expelled from the coral. …”
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691
The impact of intermittent fasting during Ramadan on psychomotor and cognitive skills in adolescent athletes
Published 2024“…Results and discussion: The obtained data illustrated that there was a decrease in SRT, CRT, VT, and MRT performances during R1 in comparison to R0 (all p < .001). …”
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692
Dose of Bicarbonate to Maintain Plasma pH During Maximal Ergometer Rowing and Consequence for Plasma Volume
Published 2022“…Six oarsmen performed “2,000-m” maximal ergometer rowing trials with BIC (1 M; 100–325 ml) and control (CON; the same volume of isotonic saline). …”
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693
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694
Use and assessment of “e-plastics” as recycled aggregates in cement mortar
Published 2019“…The obtained results, for all RPs, (especially those of 7.5% and 10%) exhibited an increase in the CS of the specimens by 15.4% and 7.8%, respectively, with the MoE decreased in both cases by 18.1% and 23.8%, respectively. …”
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695
Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte.
Published 2018“…In addition, a significant up regulation in gene and protein expression profile of stage specific cell markers for OPCs/OLs (CNPase, Galc, NG2, MOG, OLIG1, OLIG2, MBP), neurons, and astrocytes (MAP2, β-TubulinIII, GFAP) and concomitant decrease of OBNSCs pluripotency markers (Oct4, Sox2, Nestin), was demonstrated following induction of OBNSCs differentiation. …”
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696
Enhancement of mechanical and corrosion resistance properties of electrodeposited NiP-TiC composite coatings
Published 2021“…Vickers microhardness and nanoindentation results demonstrate the increase in the hardness with an increasing amount of TiC particles attaining its terminal value (593HV100) at the concentration of 1.5 g L−1. Further increase in the concentration of TiC particles results in a decrease in hardness, which can be ascribed to their accumulation in the Ni–P matrix. …”
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697
Low levels of Vitamin D during pregnancy associated with gestational diabetes mellitus and low birth weight: results from the MAASTHI birth cohort
Published 2024“…Furthermore, causal mediation analysis showed that a decrease in one unit of Vitamin D is associated with a decrease of 0.015 units of fasting blood sugar (FBS) and 0.019 units of postprandial blood sugar (PPBS) as it flows through the mediator variable insulin resistance. …”
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698
Enzymatic treatment of peanut butter to reduce the concentration of major peanut allergens
Published 2013“…Treatment of peanut butter with a combination of trypsin and alpha-chymotrypsin resulted in a decrease in IgE-binding, suggesting that enzymatic treatment has the potential to reduce the allergenicity. …”
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699
Complex-impedance response of an Ag/TeO2-V2O5/Ag structure
Published 2009“…The electrical conductance and capacitance were measured over a frequency range of 20 Hz to 1 MHz and a temperature range of 293–450 K; these reveal semiconducting features based predominantly on an ionic mechanism. …”
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700
Repositioning of the global epicentre of non-optimal cholesterol
Published 2020“…Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. …”
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