2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream by Afif Ben Salah (202439)

<i>A</i>. <i>persici</i>-conditioned diet shortens lifespan. by Taro Onuma (15195377)

<i>Symbiodinium</i> density <i>in hospite</i>. by Lisa Fujise (672628)

Non-hydrolysable ATP analogues prevent decrease of I_Ca,L by metabolic inhibition. by Giedrius Kanaporis (4405525)

The progression of pulmonary granuloma-associated fibrosis is slowed in iNOS-KO rats. by Jia Shen (1828945)

Fig 3 - by Hyun-Jun Kim (1561153)

“…E) Densitometry analysis of atrogin-1, MuRF-1, mTOR and phosphorylated mTOR expression. ** = <i>p</i><0.01 indicates significantly decreased or increased expression compared to the untreated control (n = 4).…”

The biliary injuries and cholestasis are alleviated by the decreased pro-inflammatory activation of macrophages treated with InCsEVs. by Beibei Zhang (509356)

CFDP1 and H2A.Z co-bound peaks. by Gokul Gopinathan (7930679)

Subjects:

Poly(I:C) at a low dose inhibits <i>A</i>. <i>flavus</i> induced AHR and acute eosinophilia. by Li She (2204779)

“…Administration of Poly(I:C) decreased the percentage and number of eosinophils in lungs after exposure to <i>A</i>. …”

Fig 6 - by Hyun-Jun Kim (1561153)

“…The IC₅₀ 3.49 μM, 2.94 μM, and 3.07 μM, respectively. ** = <i>p</i><0.01 and **** = <i>p</i><0.0001 indicate significantly decreased viability compared to the untreated control. …”

Fig 2 - by Hyun-Jun Kim (1561153)

“…Myoblasts were differentiated for 72 h and treated with 10 μM Dex, or 10 μM Dex plus 300 nM or 600 nM Ni or 50 ng/ml bovine insulin for 24 h. B) Average diameter of C2C12 myotubes treated with Dex or Dex+Ni. *** = <i>p</i><0.001 indicate significantly decreased compared to the untreated control. ### = <i>p</i><0.001 to indicate significantly increased myotube diameter compared to Dex treated myotubes. …”

<i>Orobanche</i> incidence (%) and <i>Orobanche</i> severity (1–9), Number of Days to <i>Orobanche</i> Emergence (NDOE) and number of Emerged Orobanche Shoots per plant (EOS) recor... by Moez Amri (10872935)

Subjects:

Everolimus decreased EC inflammation via lowered IL-1β and IL-6 expression in ECs. by Zsolt Fejes (844136)

Mean trans-epidermal water loss (TEWL) (a) and pH (b) and decrease in mRNA expression (c) in the AD <i>FLG</i>+/+, AD <i>FLG</i>+/− and the AD/IV <i>FLG</i>−/− group. by Mårten C. G. Winge (118591)

Body weight and ovarian characteristics following CR in POLG^D257A/257A female mice. by Christine Faraci (5778434)

“…<p><b>A.</b> Body weight was decreased following the onset of CR. …”

Mendelian randomization results with COVID-19. by Alish B. Palmos (5857379)

“…Using genetic instruments and under the assumptions of Mendelian randomization, the top section shows results consistent with six blood markers being significantly causally associated with an increased risk of hospitalization as a result of COVID-19 and the nine blood markers causally associated with a decreased risk of hospitalization, as well as one protein showing a decrease in risk of hospitalization. …”

The AngII-induced decrease in AdipoR1 expression involves ERK1/2 activation and ROS production. by Li Li (14993)

Tumor-induced hemoglobin decrease in TC-1 or ID8 -bearing mice is not affected by hepcidin ablation. by Airie Kim (544745)