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281
6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations
Published 2025“…F-53B also induced Parkinson’s disease (PD)-like disorders including dyskinesia (incidence: 22.8–27.9%), dopaminergic neuronal damage (neuritic blebbings and broken neurites) and decreased dopamine levels (15.2–28.1%), increased abundance (1.3–1.4 fold) and aggregation of α-synuclein. …”
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282
6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations
Published 2025“…F-53B also induced Parkinson’s disease (PD)-like disorders including dyskinesia (incidence: 22.8–27.9%), dopaminergic neuronal damage (neuritic blebbings and broken neurites) and decreased dopamine levels (15.2–28.1%), increased abundance (1.3–1.4 fold) and aggregation of α-synuclein. …”
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283
Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation.
Published 2024“…Large circles show mean of cells from 5 fields of view from a single animal. (D) Immunoblot showing p53 protein expression is decreased in colon tissue from 5-month old HA-MAD1 mice after 1 week of 6 mg/kg dox feed as compared to control. …”
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MMR mutants show decreased mating-type silencing.
Published 2020“…<b>(D)</b> Cells of indicated strains were 10-fold serially diluted and then spotted onto SC (left), SD-Ura (middle) and SC+FOA(right) agar plates, the <i>sir1Δ</i> mutant served as a positive control. …”
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Fold change in humoral and cellular response magnitudes from RV305 week 2 to week 26.
Published 2023Subjects: -
292
GSK343 decreased neuroblastoma viability, proliferation, and motility.
Published 2021“…<p>(A) SK-N-AS, SK-N-BE(2), SH-EP and WAC(2) cells (1.5 × 10<sup>3</sup> cells) were treated with increasing concentrations of GSK343 (0, 5, 15, 25 μM) for 24 hours and viability was measured using alamarBlue<sup>®</sup> assay. …”
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Decreased cell stiffness after dissociation of intercellular adhesion.
Published 2014“…The corresponding cross section height measurements show a height decrease by slightly less than 100 nm (from ∼10 nm to −100 nm in the encircled area; lower panel); the arrow in the AFM images points to an intact intercellular connection before cutting (<b>E1</b>) and the disappearance thereof after cutting (<b>E2</b>). …”
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