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Dietary L-carnitine and vitamin-E; a strategy to combat ochratoxin-A induced immunosuppression
Published 2018“…One-day old white male Leghorn chicks were divided into 12 groups, having 20 birds each and were offered ration contaminated with OA (1.0 or 2.0 mg/kg feed) alone and concurrently with LC (1.0 g/kg) and/or VE (0.2 g/kg), for 42 days. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model
Published 2018“…Findings show that Sitg (50 mg) resulted in significant decrease in IS and DPP-4 activity, and significant increase in GLP-1, NOS activity, e-NOS expression, TRPV-1 level and TRPC-1 expression, compared to controls. …”
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Response of cauliflower (Brassica oleracea L.) to nitric oxide application under cadmium stress
Published 2022“…The present study examined the putative roles of nitric oxide (NO) in improving Cd-tolerance in cauliflower (Brassica oleracea L.). The present study was conducted using four different genotypes of B. oleracea named as FD-3, FD-4, FD-2 and Ceilo Blanco which were subjected to the Cd stress at various concentrations i.e., 0, 5, 10 and 20 µM with or without the application of NO i.e., 0.10 mM in the sand containing nutrient Hoagland’s solution. …”
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Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
Published 2022“…As such, alternative approaches that may provide some benefit in fighting this debilitating pathology are critically needed; hence the utilization of herbal medicine. Origanum syriacum L., one of the most regularly consumed plants in the Mediterranean region, exhibits antiproliferative effect on several cancer cell lines. …”
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Salicylic acid restricts mercury translocation by activating strong antioxidant defense mechanisms in sweet pepper (Capsicum annum L.)
Published 2023“…Spraying of 100 μM SA at three different Hg levels, i.e., 0 μM, 50 μM, 100 μM, and 150 μM. The maximum decrease in photosynthetic machinery, plant growth attributes (shoot length, root length, no. of leaves, fresh and dry biomass (shoot and root)), and more accumulation of Hg in leaves, roots, and fruits of sweet pepper. …”
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Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
Published 2022“…Protein levels of markers of apoptosis (BCL-2, pro-Caspase3, p53), proliferation (p21, Ki67), cell migration, invasion, or adhesion (FAK, E-cadherin), angiogenesis (iNOS), and cell signaling (STAT3, p38) were determined by immunoblotting. …”
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Silicon Enhances Morpho–Physio–Biochemical Responses in Arsenic Stressed Spinach (Spinacia oleracea L.) by Minimizing Its Uptake
Published 2022“…For this purpose, we have designed the current experiment to explore the contribution of Si in mediating growth and eco-physiology by alleviating As stress in a leafy vegetable spinach (Spinacia oleracea L.). Fifteen days old seedlings of S. oleracea were subjected to the different concentrations of As, i.e., 0 (no As), 50, and 100 µM in the soil which were also supplied with the different exogenous levels of Si, i.e., 0 (no Si), 1.5, and 3 mM. …”
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Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
Published 2017“…Prior exposure to PI3K inhibitors, wortmannin (0.1 µM) or LY294002 (10 µM), decreased cGMP accumulation and attenuated the SF-induced vasorelaxation by approximately 50% (Rmax). …”
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