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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…In cardiac muscle, CaM modulates directly or indirectly the activity of several proteins that play a key role in excitation-contraction coupling (ECC), such as ryanodine receptor type 2 (RyR2), l-type Ca2+ (Cav1.2), sodium (NaV1.5) and potassium (KV7.1) channels. …”
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Bio-Inspired Fabrication of Ultrafiltration Membranes Incorporating Polydopamine Functionalized Graphene Oxide Nanoparticles
Published 2021“…Thus, the flux increased with the embedding of rGO-PDA without affecting the rejection properties, while it decreased with the embedding of pristine GO. The highest pure water permeability (PWP) was obtained with PSF/rGO PDA-0.1 to be approximately twice that of the pristine PSF and PSF/GO-0.1. …”
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Tests of a diamond field-assisted positron moderator
Published 2002“…The film was coated on one side with a 200 nm gold electrode and on the other with a similar thickness of gold in the form of a fine mesh (10 μm lines, 40 μm spaces) in the central part of the diamond surface and a solid edge for electrical contact. …”
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Evaluating the effect of glycaemic control, blood pressure, lipid profile and diabetes duration on developing diabetes complications and its progression
Published 2018“…Purpose: This study was aimed to evaluate the effect of glycaemic control, blood pressure, lipid profile and diabetes duration on developing diabetes complications and its progression. Methods: One thousand and fourteen patients attending outpatient diabetes clinic at a hospital in the northern part of Malaysia were retrospectively followed. …”
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Tailoring optical absorption in silicon nanostructures from UV to visible light: A TDDFT study
Published 2016“…Our main findings are that: (i) The oscillator strength as a function of length is quadratic at small lengths, and then increases linearly. …”
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Gelation of Emulsified Polyacrylamide/Polyethylenimine under High-Temperature, High-Salinity Conditions: Rheological Investigation
Published 2018“…It is suggested that the emulsification acts as an insulator, hence heat transfer to the gelant is slow. The elastic (i.e., storage) modulus of the emulsified PAM/PEI increased by about 29% when the temperature was raised from 120 to 150 °C. …”
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Gamma irradiation effects on polymethyl methacrylate
Published 2007“…3), attributed to ortho-positronium (o-Ps) decay, and the intensity of this component (I3) was studied by positron annihilation lifetime spectroscopy (PAL). …”
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Correlation between delta-endotoxin and proteolytic activities produced by Bacillus thuringiensis var. kurstaki growing in an economic production medium
Published 2013“…Maximal protease activity (540-2468 UI) obtained by BUPM5-1 and BUPM5-2 was 2.34-fold and 10.7-fold, respectively, more than that obtained by the wild strain BUPM5 with a drastic decrease of their delta-endotoxin production. …”
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