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Delphinidin alters VEGF-A splicing to increase VEGF-A<sub>165</sub>b and decrease total VEGF-A expression.
Published 2019“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A<sub>165</sub>b relative to total VEGF-A<sub>165</sub> (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A<sub>165</sub>b before stripping and reprobing with panVEGF-A). …”
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Metformin inhibits glutaminase activity in a dose dependent manner: from 17.5% at 10 mM up to 68% at 100 mM (A) (* p<0.05).
Published 2014“…<p>This effect, analyzed by Dixon plot, showed competitive inhibition kinetics, with a K<sub>i</sub> of 14.28 mM (B). In Caco2 cells, metformin 20 mM showed 24% inhibition of glutaminase activity at 72 hours compared to control cultures (p<0.05) (glutamate production was decreased from 26.85±0.74 µM to 19.9±2.05 µM; p<0.05) (C).…”
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HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 1
Published 2019Subjects: -
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The <i>P[syt<sup>P-L</sup>]</i> mutation decreases the Ca<sup>2+</sup> affinity of release and vesicular release probability, but the readily releasable pool is unchanged.
Published 2017“…<p>(A) Mean EJP amplitudes from <i>+/-;P[syt<sup>WT</sup>]/+</i> (filled black circles) and <i>+/-;P[syt<sup>P-L</sup>]/+</i> (filled red circles) larvae at Ca<sup>2+</sup> levels ranging from 0.05 mM—5.0 mM. …”
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Chemokines, with the exception of CXCL1 and MCP-1, decrease acutely following 5 Gy IR.
Published 2024Subjects: -
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sC5b-9 patients decrease in patients treated with mycophenolate mofetil.
Published 2015“…When analyzed separately based upon treatment, the decrease in sC5b-9 levels was due to a decrease in patients treated with mycophenolate mofetil (P < 0.001 by linear regression; n = 12 for all time-points). …”
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MK-STYX decreases RhoA activation.
Published 2014“…<p>(<b>A</b>) PC12 cells were transfected with pMT2 or pMT2-FLAG-MK-STYX-FLAG. 24 hr post-transfection cells were stimulated with 100 ng/ml NGF, and lysed at the indicated time points. …”