Image_2_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…</p>Methods<p>To investigate the mechanisms of gender differences in SIRT1 skeletal effect, we investigated femoral and vertebral cortical and cancellous bone in global Sirt1 haplo-insufficient 129/Sv mice aged 2,7,12 months lacking Sirt1 exons 5,6,7 (Sirt1^+/Δ) and their wild type (WT) counterparts.…”

Image_1_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…</p>Methods<p>To investigate the mechanisms of gender differences in SIRT1 skeletal effect, we investigated femoral and vertebral cortical and cancellous bone in global Sirt1 haplo-insufficient 129/Sv mice aged 2,7,12 months lacking Sirt1 exons 5,6,7 (Sirt1^+/Δ) and their wild type (WT) counterparts.…”

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

Delayed expression kinetics of the <i>PHO5</i>, but not the <i>lacZ</i> gene under regulation of the <i>PHO5</i> promoter in <i>rrp6Δ</i> mutant cells. by Ana Novačić (8373573)

Comparison of ODE models (5) and (6). by Manuel Mai (497861)

Podocyte numbers in control and iPLA₂γ KO mice (WT1-positive cells). by Andrey V. Cybulsky (4007012)

Follistatin expression is decreased and the MAPK signaling pathway is activated in <i>Med1^epi−/−</i> mice keratinocytes <i>in vitro</i>. by Fumihito Noguchi (615295)

Kcnk5b enhanced depolarization is required for enhanced fin bud growth. by Xiaowen Jiang (8291814)

The overall negative effects played by IFITM3 during viral spread are the result of two concomitant antiviral mechanisms, acting in the protection of target cells as well as in the... by Kevin Tartour (514249)

Decreased proliferation in <i>AnxA2</i>kd and <i>AnxA5</i>kd cells. by Damian C. Genetos (325684)

CD43^-/- septic mice exhibit decreased frequencies of apoptotic CD4⁺ and CD8⁺ naïve T cells as compared to WT septic mice. by Katherine T. Fay (2576998)

“…B) CD43^-/- septic mice exhibited a decreased frequency of apoptotic naïve CD4⁺ T cells, defined as 7-AAD⁺ Annexin V⁺ CD44^LO CD62L^HI CD4⁺ cells, compared to WT septic mice (11.8±1.6 vs 18.8±1.3, p = 0.002. …”

Descriptive statistics of all results at baseline after a full night of sleep (0 h), after 12 (-12 h), 24 (-24 h) and 36 (-36 h) hours of total sleep deprivation followed by 8 (+8... by Jan Maleček (17396660)

Subjects:

<i>ERG251</i> heterozygous deletion mutants maintain their pathogenicity in a murine model. by Xin Zhou (54275)

Response of I_Ca,L to IBMX in WT and AMPKα2-/- mice AVMs. by Anne Garnier (130125)

Subjects:

Decreased Aβ oligomer immunoreactivity in APPxPS1 mice after treatment with hNGFP61S/R100E: scFV A13 antibody. by Simona Capsoni (161132)

Decreasing NR1 and NR2A gene expression in 5-, 14- and 21-day groups. by Chenxia Han (4020017)

Dynamics of PtdIns(4,5)P₂ levels in protrusion membrane during <i>S</i>. <i>flexneri</i> cell-to-cell spread. by Volkan K. Köseoğlu (12055346)

Both with somatic and with dendritic stimulation, pyramidal cell burst firing decreases as the apical dendrite becomes shorter. by Ronald A. J. van Elburg (80591)

Both with somatic and with dendritic stimulation, pyramidal cell burst firing decreases as the apical dendrite becomes shorter. by Ronald A. J. van Elburg (80591)

The Type 2 Diabetes Risk Allele of <i>TMEM154</i>-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes by Marie Neergaard Harder (232759)

“…Significant associations between <i>TMEM154</i>-rs6813195 and the beta cell measures insulinogenic index and disposition index and between <i>FAF1</i>-rs17106184 and 2-hour serum insulin levels were selected for further investigation in additional Danish studies and results were combined in meta-analyses including up to 6,486 Danes.</p><p>Results</p><p>We confirmed associations with type 2 diabetes for five of the seven SNPs (<i>TMEM154</i>-rs6813195, <i>FAF1</i>-rs17106184, <i>POU5F1/TCF19</i>-rs3130501, <i>ARL15</i>-rs702634 and <i>ABCB9/MPHOSPH9</i>-rs4275659). …”