Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Overview of the WeARTolerance program. by Ana Beato (20489933)

“…The quantitative results from Phase 1 demonstrated a decreasing trend in all primary outcomes. …”

Raw data of the results in all figures. by Ying-Chou Chen (263436)

Subjects:

Cost-effectiveness analysis of universal varicella vaccination in Turkey using a dynamic transmission model by Lara J. Wolfson (7224623)

“…Inclusion of a second dose is being considered.</p><p>Methods</p><p>We developed a dynamic transmission model to evaluate three vaccination strategies: single dose at 12 months (1D) or second dose at either 18 months (2D-short) or 6 years of age (2D-long). …”

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

“…Mitochondrial uncouplers such as BAM15 increase respiration and energy expenditure and have potential in treating a variety of metabolic diseases. In this study, we disclose the structure–activity relationship profile of 6-substituted [1,2,5]oxadiazolo[3,4-<i>b</i>]pyridin-7-ol derivatives of BAM15. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Decreased proliferation in <i>AnxA2</i>kd and <i>AnxA5</i>kd cells. by Damian C. Genetos (325684)

Supplementary Material for: Decreasing Trend in Incidence of Late Onset Culture Positive Bloodstream Infections but Not Late Onset Meningitis in Preterm Infants <33 Weeks Gestation... by Zhou Q. (4138852)

“…<b><i>Conclusions:</i></b> There was a decreasing trend of late onset CPBSI but not late onset meningitis. …”

Kcnk5b enhanced depolarization is required for enhanced fin bud growth. by Xiaowen Jiang (8291814)

Calculation of dark-field-to-attenuation CNR ratios of <i>in vivo</i> porcine lung tissue. by Fabio De Marco (5797991)

Room-Temperature Photoferroelectrics Semiconductor Driven by the Interlayer Confinement Effect by Yueyue He (10821234)

Subjects:

Room-Temperature Photoferroelectrics Semiconductor Driven by the Interlayer Confinement Effect by Yueyue He (10821234)

Subjects:

Decreasing NR1 and NR2A gene expression in 5-, 14- and 21-day groups. by Chenxia Han (4020017)

S1 Data - by Emily Baker (3492485)

“…Variability in the estimation of SNP-based heritability could explain the differences in reported heritability.</p><p>Methods</p><p>We compute heritability in five large independent cohorts (N = 7,396, 1,566, 803, 12,528 and 3,963) to determine whether a consensus for the AD heritability estimate can be reached. …”

Downregulation of DOM decreases the abundance of PER and TIM. by Zhenxing Liu (399809)

“…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …”

S1 File - by Molly L. Tolins (17319103)

“…<div><p>Background</p><p>The practice of medicine faces a mounting burnout crisis. Physician burnout leads to worse mental health outcomes, provider turnover, and decreased quality of care. …”