Image_5_Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.jpeg by Giulia Monticone (13431972)

“…Tumor-induced immunosuppression diminishes the effectiveness of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In this study, we describe a new immunosuppressive pathway in which adenosine promotes Casitas B-lineage lymphoma b (Cbl-b)-mediated Notch1 degradation, causing suppression of CD8+ T-cells effector functions. …”

Data_Sheet_1_Genetically Predicted Higher Educational Attainment Decreases the Risk of COVID-19 Susceptibility and Severity: A Mendelian Randomization Study.docx by Zhongyu Jian (11475802)

“…</p><p>Methods: We identified genetic instruments for EA from a large genome-wide association study (GWAS) (n = 1,131,881). …”

Image_1_Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3).JPEG by Vania A. Figueroa (8332773)

Table_1_Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3).DOCX by Vania A. Figueroa (8332773)

Table_1_Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3).DOCX by Vania A. Figueroa (8332773)

DataSheet_1_Changing Trends in Melanoma Incidence and Decreasing Melanoma Mortality in Hungary Between 2011 and 2019: A Nationwide Epidemiological Study.docx by Gabriella Liszkay (10135301)

“…</p>Conclusions<p>We observed a significant trend change in melanoma incidence in the female and total melanoma population, and a significant decrease in mortality in the total melanoma population. …”

Image_1_Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3).JPEG by Vania A. Figueroa (8332773)

Changes in the presence of metabolites within LTSP media, during the first 32 days of adaptation. by Sophia Katz (484784)

DataSheet_1_Exogenous spermine alleviates the negative effects of combined salinity and paraquat in tomato plants by decreasing stress-induced oxidative damage.pdf by Lidia S. Pascual (15429197)

Table_5_Arabidopsis Histone Methyltransferase SUVH5 Is a Positive Regulator of Light-Mediated Seed Germination.DOCX by Dachuan Gu (6790856)

“…Here, we identified SUVH5, a histone H3 lysine 9 methyltransferase, as a positive regulator in light-mediated seed germination in Arabidopsis. …”

Data Sheet 5_A lactylation-ferroptosis cross-talk gene signature predicts hepatocellular carcinoma prognosis and reveals STMN1/PRDX1 as therapeutic targets.zip by Jiali Meng (4799928)

“…</p>Discussion<p>We identified the first lactylation-ferroptosis cross-talk signature to predict HCC prognosis and identified STMN1/PRDX1 as potential targets for treating HCC by stratifying therapies.…”

Mutations in the Cholesterol Transporter Gene <i>ABCA5</i> Are Associated with Excessive Hair Overgrowth by Gina M. DeStefano (564953)

“…We identified a single base pair substitution in the 5′ donor splice site of intron 32 in the ABC lipid transporter gene <i>ABCA5</i> that leads to aberrant splicing of the transcript and a decrease in protein levels throughout patient hair follicles. …”

Image_1_Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease.TIFF by Wei Huang (36889)

Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner by Khondoker Alam (1443499)

“…Compared with vehicle control treatment, bortezomib pretreatment significantly decreased the maximal transport velocity (V_max) of OATP1B3-mediated transport of CCK-8 (92.25 ± 14.2 vs. 133.95 ± 15.5 pmol/mg protein/min) without affecting the affinity constant (K_m) values. …”

Effect of protein size on the relationship between site-specific evolutionary rates and distance to the nearest catalytic residue. by Benjamin R. Jack (2637040)

“…The addition of distance to a structural-constraints (RSA and WCN) model increases the accuracy of rate prediction near the active site up to shell 3 (17.5 Å) in small proteins and up to shell 5 (27.5 Å) in large proteins. …”

Multivariate-adjusted odds ratios for the cause-specific mortality (A: cardiac death, B: cerebrovascular death, C: infection-related death, D: cancer-related death) according to BM... by Yukitoshi Sakao (2547880)

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Multivariate-adjusted odds ratios for all-cause mortality according to BMI categories. by Yukitoshi Sakao (2547880)

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Multivariate-adjusted odds ratios for the cause-specific mortality (A: cardiac death, B: cerebrovascular death, C: infection-related death, D: cancer-related death) according to BM... by Yukitoshi Sakao (2547880)

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Associations of BMI with morbidities according to Cr levels in female. by Yukitoshi Sakao (2547880)

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Patient selection. by Yukitoshi Sakao (2547880)

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