Diurnal Glycemic Patterns during an 8-Week Open-Label Proof-of-Concept Trial of Empagliflozin in Type 1 Diabetes by Bruce A. Perkins (312635)

“…</p><p>Results</p><p>The 40 patients (26 on insulin pump) were aged 24±5 years and BMI 24.5±3.2 kg/m². Consistent with the observed HbA1c decrease (8.0±0.9% to 7.6±0.9%, p<0.0001), normalized AUC_TOTAL CGM decreased from 153.7±25.4 to 149.0±30.2mg/dL∙h at end-of-treatment (p = 0.31), and significantly increased post-treatment (164.1±29.5mg/dL∙h, p = 0.02). …”

Antioxidation and Anti-Inflammatory Activity of Prussian Blue Nanozymes to Alleviate Acetaminophen-Induced Acute Liver Injury by Qiang Feng (88137)

Subjects:

AM induces decreased contrast detection performance. by Nathalie Van Humbeeck (3270255)

Image_2_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…</p>Methods<p>To investigate the mechanisms of gender differences in SIRT1 skeletal effect, we investigated femoral and vertebral cortical and cancellous bone in global Sirt1 haplo-insufficient 129/Sv mice aged 2,7,12 months lacking Sirt1 exons 5,6,7 (Sirt1^+/Δ) and their wild type (WT) counterparts.…”

Image_1_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…</p>Methods<p>To investigate the mechanisms of gender differences in SIRT1 skeletal effect, we investigated femoral and vertebral cortical and cancellous bone in global Sirt1 haplo-insufficient 129/Sv mice aged 2,7,12 months lacking Sirt1 exons 5,6,7 (Sirt1^+/Δ) and their wild type (WT) counterparts.…”

Significantly decreased adhesion to host cells by the Δ<i>tad123</i> mutant (A) and time-dependent recovery (B). by Tra-My Duong-Nu (7300970)

The reconstructed temperature signal <i>T</i>_<i>S</i>5, depicted for various values of <i>ε</i>, is a valuable tool for assessing the effect of positive and negative tem... by Cyrine Chenaoui (22177098)

<b>Nest mass in forest tits </b><b><i>Paridae</i></b><b> </b><b>increases with elevation and decreasing body mass, promoting reproductive success</b> by Clara Wild (19246606)

“…Nest boxes were installed along an elevational gradient of approximately 1000 m a.sl., either in forest gaps with fluctuating microclimatic conditions or in closed forests with buffered microclimates. We found that nest mass increased by ~ 60% along the elevational gradient, but the effect of canopy openness on nest mass was not significant, while nest mass decreased along the ranked species from the smallest <i>Periparus ater</i> to the medium-sized <i>Cyanistes caeruleus</i> and the largest <i>Parus major</i>. …”

Serum estradiol concentrations in study (n = 9) and control (n = 5) bitches during the luteal phase, from days 8 to 27 after the estimated LH peak. by Kamil Kacprzak (713647)

Serum progesterone concentrations in study (n = 9) and control (n = 5) bitches during the luteal phase, from days 8 to 27 after the estimated LH peak. by Kamil Kacprzak (713647)

ITGαV-silenced cells exposed to CSE showed a partial decrease in TGF-β activation. by Marco Checa (2549590)

Overexpression of TNFAIP9 suppressed inflammation in mouse peritoneal macrophages caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Subjects:

Modifying pregnenolone to decrease its lipophilicity results in decreased cellular uptake. by Jeffrey M. McManus (7512926)

Results of sensitivity analysis of risk categorization for shorebird species. by Hector Galbraith (636637)

Localization of key HH signaling proteins is impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa by Andrej Emanuel Cotman (5203904)

“…Starting from DNA gyrase inhibitor <b>1</b>, we identified compound <b>27</b>, featuring a 10-fold improved aqueous solubility, a 10-fold improved inhibition of topoisomerase IV from A. baumannii and P. aeruginosa, a 10-fold decreased inhibition of human topoisomerase IIα, and no cross-resistance to novobiocin. …”

Decreased prevalence of circulating CXCR5+CD4+ Tfh cells predicts a poor survival in HCC. by Yiqiong Jia (692871)

WNF decreases Aβ peptides generation in HEK293 and SH-SY5Y human cells. by Htut Htut Htoo (3686641)

Botulinum toxin A (3.5 U/kg) decreases dural extravasation in IoNC injured rats. by Boris Filipović (336089)

No contribution of TGF-α, protein phosphatase 5 or protein kinase A to decreased levels of secreted Hsp90. by Stefan Tukaj (439533)