Search alternatives:
wt decrease » we decrease (Expand Search), _ decrease (Expand Search), nn decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
1 wt » _ wt (Expand Search), 1 st (Expand Search), i wt (Expand Search)
wt decrease » we decrease (Expand Search), _ decrease (Expand Search), nn decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
1 wt » _ wt (Expand Search), 1 st (Expand Search), i wt (Expand Search)
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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Decreased synaptic density in the CA1 hippocampal area.
Published 2013“…Importantly, the total number of PSD-95/SYN contacts (synaptic density) was also decreased in the AS mouse (I). Western blot analysis of WT and AS hippocampus shows no visual differences in PSD-95 levels between WT and AS mice (J); however, there was roughly a 35% lower level of expression of SYN in AS than in WT. …”
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CD43<sup>-/-</sup> septic mice exhibit decreased frequencies of apoptotic CD8<sup>+</sup> T<sub>EM</sub> as compared to WT septic mice.
Published 2018“…D) There was a significant decrease in apoptosis of CD44<sup>HI</sup> CD62L<sup>LO</sup> CD8<sup>+</sup> T<sub>EM</sub> in CD43<sup>-/-</sup> septic mice compared to WT septic mice (10.3±1.1 vs 17.9±1.9, p = 0.006). …”
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