Capsaicin, pyridoxine, vincristine sulfate and ionomycin significantly decreased axon length ratio but only pyridoxine had no impact on neurotoxicity. by Fei San Lee (17282886)

“…Although, axon length ratio was significantly lower than EtOH control across all days, 770 nM Imy axonal dieback is very slow. (<b>B, D, F, H</b>) LDH assay revealed that Caps, 100 nM Vcr and 770 nM Imy induced significant increase in percentage of cytotoxicity compared to respective solvent control. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

Subjects:

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

Subjects:

Prevalence of smoking during COVID19 (n = 1844). by Mahmoud A. Alomari (14780446)

Repetitive stress induces a decrease in sound-evoked activity. by Ghattas Bisharat (20706928)

“…Activity rates decreased during repeated stress compared to baseline (2-way ANOVA, condition F = 185.6, <i>p</i> = 4.8 × 10⁻⁴², condition: intensity interaction F = 10.37, <i>p</i> = 9.3 × 10⁻²¹, nested ANOVA (mouse nested within session), condition F = 174, <i>p</i> = 1.5 × 10⁻³⁹, condition: intensity interaction F = 12.7, <i>p</i> = 2 × 10⁻²⁶, post hoc for each level baseline versus repetitive stress <i>p</i> < 0.01 for all levels above 50 dB, all Bonferroni corrected). …”

RAC1 inhibition results in a decrease in oxidative phosphorylation. by Shruthi Sriramkumar (12705564)

The motor torque curves of load increase/decrease (A) the load of 10 N • m (B) the load of 20 N • m. by Taochang Li (20642935)

“…<p>The motor torque curves of load increase/decrease (A) the load of 10 N • m (B) the load of 20 N • m.…”

The motor speed curves of load increase/decrease (A) the load of 10 N • m (B) the load of 20 N • m. by Taochang Li (20642935)

“…<p>The motor speed curves of load increase/decrease (A) the load of 10 N • m (B) the load of 20 N • m.…”

Genes whose expression was decreased by 1 mM ouabain by more than 2-fold. by Larisa V. Smolyaninova (3600053)

Comparison of mean differences in temperature decreases. by Hans-Jörg Gillmann (8460585)

Lymphocytes decreased in mouse pneumonia model. by Qi Xu (134661)

Running decreased hippocampal amyloid burden. by Kaja Falkenhain (9317016)

Ellagic acid decreases mitochondrial damages. by Ahmad Salimi (10204515)

Relative expression of (A) miR-214 and (B) the <i>ATF4</i> target gene after transfection with 40 nM of miR-214 mimics or a negative mimics control for 24 h, followed by treatment... by Tipparat Penglong (164413)

Loss of Prox1a decreases PR production at 120 hours post-ablation. by Kellie Veen (17343374)

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”