Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

Subjects:

Localization of key HH signaling proteins is impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

T0 treatment significantly decreased soluble Aβ oligomers, but not amyloid plaque pathology in APP/E4/Abca1^+/- mice. by Alexis Y. Carter (3798223)

“…N.S., not significant. <b>E,</b> T0 treatment significantly decreases Aβ oligomers in APP/E4/Abca1^+/- mice. …”

GSH depletion leads to a strong decrease in SCF-dependent HIF-1α PHD activity in LAD2 cells. by Bernhard F. Gibbs (328262)

TNFα, MIP-1α, and MCP-1 are decreased and anti-inflammatory cytokine IL-10 is increased by MSC treatment. by Shibani Pati (208746)

“…<p>Blood was drawn at two hours post-hemorrhage and analyzed for serum levels of TNFα, MCP-1, IL-10 and MIP-1α. As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025171#pone-0025171-g005" target="_blank">Figures 5A–C</a>, bioplex analysis of serum shows that MCP-1, TNFα, and MIP-1α all significantly increase after HS and HS+LR. …”

FASN inhibitors result in decreased ΔΨm and increased superoxide production in melan-a cells. by Franco A. Rossato (588513)

FASN inhibitors result in decreased ΔΨm and increased superoxide production in melan-a cells. by Franco A. Rossato (588513)

GFP expression decreases upon differentiation towards pancreatic progenitor cells. by Nicole A. J. Krentz (669397)

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. by Kenichi Morii (6843554)

Cells with higher expression of a housekeeping gene have a decreased expression of viral genes. by Efrat M. Cohen (3384470)

Ba₂NaClP₂O₇: Unprecedented Phase Matchability Induced by Symmetry Breaking and Its Unique Fresnoite-Type Structure by Jie Chen (5892)

“…Herein, we report a unique Ba₂NaClP₂O₇ representing the first phase-matchable example of the fresnoite family, which exhibits excellent NLO properties, including short absorption edge (<176 nm, ca. 7.0 eV), strong second-harmonic generations at the incident lasers of 850–1110 nm (obv. 0.9–1.3 × KDP; cal. …”

Mutations in the flexible residue, Arg358, decrease sensitivity to bile acid germinant. by Amy E. Rohlfing (6919355)

Quantitative immunofluorescence of Sox10 in mouse OLs after CRISPRi knockdown of EC1 and EC2. by Hongjoo An (21703199)

Subjects:

Image_2_MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-... by Mithu De (11753069)

Table_2_MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-... by Mithu De (11753069)

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease by Christine M. LaPash Daniels (796881)

eIF2A interacts with the RNA binding protein Ssd1. by Laura Meyer (4033793)

TachypleginA treatment causes a decrease in the motor activity of the TgMyoA motor complex. by Aoife T. Heaslip (207534)

The phosphorylation sites we identified in both ULK1 and ATG13 are conserved between different isoforms. by Zhiyuan Li (205620)

Xrn1 depletion and eIF2A deletion are synthetic lethal. by Laura Meyer (4033793)