Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros حسب Mesmar, J.

"…In addition, ZNE significantly decreased the migratory and invasive capacity of Capan-2 with a concomitant downregulation of integrin α2 and increased cell–cell aggregation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Al-Hamdani, Mohammed

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Silicon Enhances Morpho–Physio–Biochemical Responses in Arsenic Stressed Spinach (Spinacia oleracea L.) by Minimizing Its Uptake حسب Saleem, Muhammad Hamzah

"…Silicon (Si), being an important fertilizer element, has been found effective in enhancing plant tolerance against biotic and abiotic stresses. For this purpose, we have designed the current experiment to explore the contribution of Si in mediating growth and eco-physiology by alleviating As stress in a leafy vegetable spinach (Spinacia oleracea L.). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Use and assessment of “e-plastics” as recycled aggregates in cement mortar حسب Makri, Chrysanthi

"…The obtained results, for all RPs, (especially those of 7.5% and 10%) exhibited an increase in the CS of the specimens by 15.4% and 7.8%, respectively, with the MoE decreased in both cases by 18.1% and 23.8%, respectively. …"
احصل على النص الكامل
احصل على النص الكامل

Dicarbonyl stress, protein glycation and the unfolded protein response حسب Rabbani, Naila

"…We propose that dicarbonyl stress, through increased formation of MG-glycated proteins, may be an important physiological stimulus of the UPR and Glo1 inducers may provide a route to effective suppression and therapy. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Climatic Aridity Gradient Modulates the Diversity of the Rhizosphere and Endosphere Bacterial Microbiomes of Opuntia ficus-indica حسب Karray, Fatma

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity حسب Gupta, Vijay

"…To overcome this issue, we engineered single-chain variable fragments (scFvs) against fibrillar α-syn, a putative disease-relevant form of α-syn. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway حسب Sampath, Chethan

"…Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue. …"
احصل على النص الكامل
احصل على النص الكامل

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer حسب Ashour, Amal

"…Results In high glucose concentration cultures, there was a ca. twofold increase in cellular MG, cellular protein MG-H1 content and decreased attachment of PDLFs to collagen-I. …"
احصل على النص الكامل
احصل على النص الكامل

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model حسب Abou-Saleh, Haissam

"…Although the observed toxic effect failed to affect embryo survival, whether a prolonged ChNP treatment may induce other potentially harmful effects remains to be elucidated. …"
احصل على النص الكامل
احصل على النص الكامل

Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM حسب Elrahmani, Ahmed

"…In this work, we present a coupled computational fluid dynamics-discrete element method (CFD-DEM) based modelling framework that is capable of simulating the migration of a large number of fine particles, on the colloids size through physically realistic porous media. …"
احصل على النص الكامل
احصل على النص الكامل

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. حسب Ardah, Mustafa T

"…In order to investigate the inhibitory mechanisms of these two compounds towards fibril formation, we demonstrated that salvianolic acid B binds predominantly to monomers, while dihydromyricetin binds to oligomeric species and to a lower extent to monomers. …"
احصل على النص الكامل
احصل على النص الكامل

The maxima in northerly wind speeds and wave heights over the Arabian Sea, the Arabian/Persian Gulf and the Red Sea derived from 40 years of ERA5 data حسب Aboobacker, V.M.

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) حسب Hamad, Anas

"…Background: In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …"
احصل على النص الكامل
احصل على النص الكامل

Dynamic Distributed Multi-Path Aided Load Balancing for Optical Data Center Networks حسب Wang, Fu

"…This paper establishes a leaf-spine Hoe-DCN model to illustrate the principal characteristic of dynamic load balancing in TOR switches for the first time. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Impact of COVID-19 lockdown on smoking (waterpipe and cigarette) and participants' BMI across various sociodemographic groups in Arab countries in the Mediterranean Region حسب Al Sabbah, Haleama

"…CONCLUSIONS: Although the overall rates of smoking among the studied countries decreased during the lockdown period, we cannot attribute this change in smoking behavior to the lockdown. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Cry1Ac toxicity enhancement towards lepidopteran pest Ephestia kuehniella through its protection against excessive proteolysis حسب Elleuch, Jihen

"…However, the widespread use of B. thuringiensis δ-endotoxins has often been challenged by a lack of understanding of the target insect physiology as well as its midgut biochemistry.In the present investigation, we have evidenced and explained the toxicity improvement of Cry1Ac δ-endotoxins against Ephestia kuehniella larvae through in vivo combination with P20 helper protein. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and ma... حسب Salagre, D.

"…Obese ZDF rats and lean littermates (ZL) of both sexes were subdivided into two subgroups: control (C) and 12 weeks orally melatonin treated (M) (10 mg/kg/day). Compared to the control groups, melatonin decreased the body weight gain and visceral fat in ZDF rats of both sexes. …"
احصل على النص الكامل
احصل على النص الكامل

Molecular epidemiology and genotype distribution of Human Papillomavirus (HPV) among Arab women in the state of Qatar حسب Bansal, Devendra

"…In contrast to Western countries, we report a varied genotypic profile of HPV with a high prevalence of low-risk HPV genotype 81 among the Arab women residing in Qatar.…"
احصل على النص الكامل
احصل على النص الكامل

Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart حسب Akhtar, Saghir

"…Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation (G7, G6, G5, G4 and G3) and surface chemistry (-NH2, -COOH and -OH) on cardiac function in mammalian hearts following ischemia-reperfusion (I/R) injury, and (b) determined if any PAMAM-induced cardiotoxicity could be mitigated by Angiotensin-(1-7) (Ang-(1-7), a cardioprotective agent. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل