Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T... by Jiaxing Zhao (3965057)

“…To mitigate the systemic adverse effects of tofacitinib, 5-ASA–PABA–MAC and 5-ASA–PABA–diamine colon-specific delivery systems were constructed, and tofacitinib azo prodrugs <b>9</b> and <b>20a–20g</b> were synthesized accordingly. …”

Five-hours-old clots were subjected to scanning electron microscopy. by Jan Víteček (11434774)

Silencing of TET3 acted to decrease mitochondrial respiration in N2A cells. by Valeria Leon Kropf (17797623)

eIF5a is up-regulated in unruptured AAAs and decreased in ruptured AAAs. by Dong Ma (584680)

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Self-Diffusive Properties of the Intrinsically Disordered Protein Histatin 5 and the Impact of Crowding Thereon: A Combined Neutron Spectroscopy and Molecular Dynamics Simulation S... by Eric Fagerberg (6662456)

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HSP90 inhibition by RGRN-305 and 17-AAG decreased proinflammatory protein secretion. by Hakim Ben Abdallah (14578241)

A summary of the included study characteristics. by Zahra Tajik (20752452)

“…The results show that one month after the NSPT, there was no significant difference in the mean visfatin level of GCF (SMD: -3.91, 95%CI: -9.83, 2.01, p = 0.195, I-square, 96.6%, random effect model, n = 2) and serum (SMD: -0.33, 95%CI: -0.98, 0.33, p = 0.332, fixed effect model, n = 1), but 2, 3 and 6 months after NSPT, the mean visfatin level of GCF and serum decreased significantly. There is no significant difference one month after NSPT in diabetic patients (SMD: -5.83, 95%CI: -15.5, 3.83, p = 0.237, I-square, 97.4%, random effects model, n = 2), but three (SMD: -2.44, 95%CI: -3.37, -1.15, p = 0.001, I-square, 75.9%, random effects model, n = 3) and six months (SMD: -2.41, 95%CI: -3.81, -1.01, p = 0.001, I-square, 78.7%, random effects model, n = 2) after the treatment, a significant decrease is observed in the mean GCF visfatin level. …”

Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol. by Kaley M. Wilburn (12060476)

Percentage decreases in scores of self-reported health, large muscle function, and mobility by chronic diseases per wave after disease incidence. by James Davis (2267599)

Image5_Immunization of Broiler Chickens With a Killed Chitosan Nanoparticle Salmonella Vaccine Decreases Salmonella Enterica Serovar Enteritidis Load.pdf by Keila Acevedo-Villanueva (10531191)

“…<p>There is a critical need for an oral-killed Salmonella vaccine for broilers. …”

RNF5 depletion decreases cellular gene expression and lytic replication through increased EphA3 and EphA4 level in iSLK.219 cells. by Xiaojuan Li (351842)

Dose-dependent inhibition of V-ATPase with Bafilomycin A1 decreases LysoTracker Red fluorescence and increases Lyso-pHluorin fluorescence. by Yarden Golan (5924594)

Fibrosis markers. by Dwight D. Harris (14484648)

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Immunoblotting for TGF-beta, alpha-actinin, MMP-13, and mTOR. by Dwight D. Harris (14484648)

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Immunoblotting for JAK, STAT, and SMAD. by Dwight D. Harris (14484648)

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Immunoblotting for insulin sensitivity markers. by Dwight D. Harris (14484648)

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Immunoblotting FOXO1 and insulin receptors. by Dwight D. Harris (14484648)

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Top 10 important features with mean decrease in Gini index (A) and distribution of minimal depth (B). by Hyun Kyung Lim (9547300)

Total ISF PGE2 concentration over time (accounting for ISF probe lag time) following intramuscular administration of either 0.1 mL saline, 0.4 mg/kg meloxicam, 2.2 mg/kg flunixin o... by Emma Nixon (11772946)

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Image_3_No Evidence for a Decrease in Physical Activity Among Swiss Office Workers During COVID-19: A Longitudinal Study.PDF by Andrea Martina Aegerter (10127111)