Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease by Xiaojuan Han (3278601)

“…</p> <p><b>Abbreviations:</b> 3-MA: 3-methyladenine; AAV: adeno-associated virus; ACTB: actin, beta; AIF1/IBA1: allograft inflammatory factor 1; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A_1; BECN1: beclin 1, autophagy related; CASP1: caspase 1; CNS: central nervous system; CQ: chloroquine; DA neurons: dopaminergic neurons; DAMPS: damage-associated molecular patterns; DAPI: 4’,6-diamidino-2-phenylindole; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; GFAP: glial fibrillary acidic protein; IP: immunoprecipitation; i.p.: intraperitoneally; Ka: kaempferol; KD: knockdown; KO: knockout; LPS: lipopolysaccharide; IL1B: interleukin 1 beta; IL6: interleukin 6; Ly: lysate; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NC: negative control; NDD: neurodegenerative diseases; NLRP3: NLR family, pyrin domain containing 3; OE: overexpression; PD: Parkinson disease; poly-Ub: poly-ubiquitin; PTM: post-translational modification; PYCARD/ASC: PYD and CARD domain containing; Rapa: rapamycin; RFP: red fluorescent protein; SN: supernatant; SNCA: synuclein alpha; SNpc: substantia nigra pars compacta; SQSTM1: sequestosome 1; TH: tyrosine hydroxylase; TNF/TNF-alpha: tumor necrosis factor; Ub: ubiquitin; WT: wild type</p>…”

Resveratrol inhibits androgen production of human adrenocortical H295R cells by lowering CYP17 and CYP21 expression and activities by Nesa Marti (3851059)

“…Only SIRT3 mRNA expression was found to be altered by resveratrol, but SIRT1, 3 and 5 overexpression did not result in a change in the steroid profile of H295R cells, indicating that resveratrol may not engage sirtuins to modulate steroid production. …”

Data_Sheet_1_The “Obesity Paradox” in Patients With HFpEF With or Without Comorbid Atrial Fibrillation.PDF by Linjuan Guo (11920172)

“…In those with AF, obesity (HR = 0.62, 95% CI: 0.40–0.95) but not overweight (HR = 0.81, 95% CI: 0.54–1.21) was associated with a decreased risk of all-cause death.</p><p>Conclusions: The “obesity paradox” assessed by BMI exists in patients with HFpEF regardless of comorbid AF.…”

Table_1_SNORD126 Promotes Hepatitis C Virus Infection by Upregulating Claudin-1 via Activation of PI3K-AKT Signaling Pathway.XLSX by Xijing Qian (9377405)

“…<p>Hepatitis C virus (HCV) infection involves a variety of viral and host factors, some of which promote the infection process. …”

Image_1_MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway.tif by Alok Tripathi (7054172)

“…Target prediction algorithm and experimental confirmation by luciferase 3’ UTR reporter assay identified LRP-6 as a direct target of miR-539-3p. Over expression of miR-539-3p in osteoblasts down regulated Wnt/beta catenin signaling components and deteriorated trabecular microarchitecture leading to decreased bone formation in ovariectomized (Ovx) mice. …”

Image_2_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.tif by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

The R3-MYB Gene <i>GhCPC</i> Negatively Regulates Cotton Fiber Elongation by Bingliang Liu (188563)

“…The only conserved R3 motif and different expression between TM-1 and fuzzless-lintless mutants suggested that it might be a negative regulator in fiber development. Transgenic evidence showed that <i>GhCPC</i> overexpression not only delayed fiber initiation but also led to significant decreases in fiber length. …”

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction by Letitia D. Jones (2819566)

“…As early as two-weeks post-infection, EcoHIV led to increased permeability of the BBB associated with decreased expression of tight junction protein claudin-5, in CD40L and platelet activation-dependent manner. …”

Data_Sheet_1_The Expression of NOX From Synthetic Promoters Reveals an Important Role of the Redox Status in Regulating Secondary Metabolism of Saccharopolyspora erythraea.docx by Xiaobo Li (118828)

“…In contrast, the lower redox ratio resulted in a decreased production of another secondary metabolite, the reddish pigment 7-O-rahmnosyl flaviolin. …”

Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells by Raffaele Strippoli (181125)

“…Analysis of signalling pathways downstream of TAK1 involved in EMT induction, showed that TAK1 inhibition reduced the transcriptional activity of NF-κB and Smad3, as well as the phosphorylation of c-jun, while enhancing Smad1–5–8 activity. These results demonstrate that TAK1 is a cross-point in a network including different pro-EMT transcription factors, such as NF-κB, Snail, AP-1 and Smads. …”

Data Sheet 1_Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson’s disease.pdf by Kara N. Presbrey (21347171)

“…For motor cortex γ, this increase was tied to learning-related cross-frequency coupling led by cortically-driven network delta (δ, 0.5–4 Hz) synchrony. More generally, coordinated network δ supported a complex pattern of learning-driven cross-frequency couplings within and between cortex and basal ganglia, including striatal lead of cortical beta (β, 12–30 Hz) activity, reflecting the specialized roles of these brain regions in motor preparation. …”

DataSheet_2_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.c... by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

Supplementary file 1_Impact on women's body satisfaction of exposure to postpartum imagery on social media.pdf by Megan L. Gow (13972959)

“…Participants were then exposed to either (1) 15 body-focused images of women with a thin-average level of adiposity; (2) as per (1) PLUS 5 postpartum-health-focused images; or (3) as per (1) PLUS 15 postpartum-health-focused images. …”

Image_3_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.tif by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

Image_2_MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway.tif by Alok Tripathi (7054172)

“…Target prediction algorithm and experimental confirmation by luciferase 3’ UTR reporter assay identified LRP-6 as a direct target of miR-539-3p. Over expression of miR-539-3p in osteoblasts down regulated Wnt/beta catenin signaling components and deteriorated trabecular microarchitecture leading to decreased bone formation in ovariectomized (Ovx) mice. …”

Fluorinated Carbon Nanotube Superamphiphobic Coating for High-Efficiency and Long-Lasting Underwater Antibiofouling Surfaces by Dongjiu Zhang (11221397)

“…In this work, we successfully prepared fluorinated carbon nanotubes through a one-step fluorination method using fluorosilane and fabricated a superamphiphobic coating using a simple spray method. …”

DataSheet_3_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.c... by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

Regulation of Feto-Maternal Barrier by Matriptase- and PAR-2-Mediated Signaling Is Required for Placental Morphogenesis and Mouse Embryonic Survival by Roman Szabo (138655)

“…Indeed, placentas of the double-deficient animals showed decreased vascularization, and the ability of placental epithelium to establish a functional feto-maternal barrier was severely diminished. …”

Image_4_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.tif by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

DataSheet_1_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.c... by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”