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781
Signaling pathways activated by PACAP in MCF-7 breast cancer cells
Published 2018“…In addition, PACAP increased the phosphorylation levels of STAT1, Src and Raf within seconds, confirming their involvement in early stages of PACAP signaling whereas maximal phosphorylation of AKT, ERK and p38 was reached 10 to 20 min later. Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …”
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782
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783
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784
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785
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786
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787
Synthesis and properties of HA/ZnO/CNT nanocomposite
Published 2018“…The goal of this study was to examine the tribomechanical properties of hydroxyapatite (HA)/ZnO and HA/ZnO/CNT composite ceramics (carbon nanotubes; with different ratios 0.5 wt%, 1.0 wt%, and 1.5 wt%). The composites were synthesized using the hydrothermal method in an autoclave. …”
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788
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789
Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats
Published 2016“…In study 4, AF43136 at 10 mg/kg decreased infarct size, similarly to the positive control CsA compared to the appropriate vehicle (39.4 ± 5.9% vs. 58.1 ± 5.4% and 45.9 ± 2.4% vs. 63.8 ± 4.1%, p < 0.05, respectively). …”
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790
Association Between Sleep Duration, Food Consumption Patterns and Obesity Among Adolescents in Qatar
Published 2020“…Multiple regression analysis revealed that as the WC and BMI increased, consumption of healthy eating pattern decreased by 25% and 10 % respectively (p<0.001) Conclusion: Lack of sufficient sleep and decreased consumption of healthy foods have an association with increased risk of being obese among adolescents…”
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791
STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
Published 2024“…Utilizing a multidisciplinary approach, including site-directed mutagenesis and DNA cloning, recombinant protein expression, affinity chromatography purification, circular dichroism spectroscopy, enzymatic assays, and in silico modeling, we assessed the impact of these mutations on CBS stability and function. …”
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792
Repositioning of the global epicentre of non-optimal cholesterol
Published 2020“…Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. …”
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793
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794
Characterization of polysulfone/diisopropylamine 1-alkyl-3-methylimidazolium ionic liquid membranes: high pressure gas separation applications
Published 2020“…TGA showed that pure PSF is a highly thermostable polymer, of which the 5% weight loss temperature is above 150 C. DSC traces show that the Tg of PSF was 149.5 C and decreases gradually for the composites. …”
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795
Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications
Published 2022“…The hemolysis of all hydrogel samples is less than 0.5%, and the blood coagulation time decreased as the hydrogel concentration increased. …”
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796
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797
Low levels of Vitamin D during pregnancy associated with gestational diabetes mellitus and low birth weight: results from the MAASTHI birth cohort
Published 2024“…For every one-unit increase in Vitamin D levels, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) decreased by nearly 18%. Furthermore, causal mediation analysis showed that a decrease in one unit of Vitamin D is associated with a decrease of 0.015 units of fasting blood sugar (FBS) and 0.019 units of postprandial blood sugar (PPBS) as it flows through the mediator variable insulin resistance. …”
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798
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…MYBPC3 variants genotype–phenotype associations remain poorly understood. We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
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799
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800
Fluctuations in cardiac stroke volume during rowing
Published 2021“…Eight nationally competitive oarsmen (mean ± standard deviation: age 21 ± 2 years, height 190 ± 9 cm, and weight 90 ± 10 kg) rowed on an ergometer at a targeted heart rate of 130 and 160 beats per minute. …”
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