A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury by Veronica Redaelli (7586621)

“…The aims of this investigation were 1- to assess acute surgical pain in mice subjected to SCI, 2- to compare the efficacy of commonly used analgesia (three buprenorphine subcutaneous injection in 48 hours, 0,15 mg/kg each) with a combination of opioid and NSAID (one subcutaneous injection of 5 mg/kg carprofen before surgery followed by three buprenorphine subcutaneous injection in 48 hours, 0,15 mg/kg each) and 3- to test if Infrared Thermography (IRT) could be a potential new Refinement method to easily assess thermoregulation, an important metabolic parameter. …”

Measurement of mitochondrial superoxide anion production in HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. by Patrick Mordel (17020879)

Activator A10 increases and inhibitor G8 decreases the rate of PMA-induced PKCε-EGFP translocation in HeLa cells. by Milla Summanen (325769)

Subjects:

No discernible effect of high-dose 5-HT_2AR blockade on error rates in the reward-size task. by Yukiko Hori (299784)

Trial profile. by Chanel Avenant (409756)

“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

Metformin lotion increases collagen I expression in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

Metformin lotion reduces α-SMA levels in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

Sost and Sclerostin Expression are Decreased and Wnt Signaling is Increased in DMP1-caPTHR1 Transgenic Mice. by Charles A. O'Brien (271071)

L-NAME but not D-NAME decreased iNOS expression of the intestinal mucosa, hepatic bacteria clearance, and IL-1β as well as TNF-α expression of the Kupffer cells in STZ-DM mice. by Shu-Han Lin (4020353)

“…STZ-DM mice were fed with an L-NAME (0.5 mg/ml) or D-NAME (0.5 mg/ml, as a control drug) in drinking water for one week. …”

Decrease of the DXR-induced genotoxicity and nongenotoxic effects of Theobroma cacao revealed by micronucleus assay by M. F. G. Boriollo (4894975)

Percent decrease of the marker pigment concentrations (mean ± standard deviation of triplicate microcosms, and the probability) treated with 1.6 mg L⁻¹ H₂O₂, as compared to the control without H₂O₂ addition, in microcosms with unfiltered and 5-μm filtered seawater. by Varunpreet Randhawa (302690)

Fig 5 - by Rajnish Prakash Singh (2847608)

Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer by Ben J. Haines (22458462)

Subjects:

Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer by Ben J. Haines (22458462)

Subjects:

DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles. by Young-Eun Yoo (323357)

“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”

Chloroquine and hydroxychloroquine decrease CXCL12-mediated proliferation in pancreatic cancer cell lines. by Joseph Kim (17521)

Fig 4 - by Sinthia Kabir Mumu (17705902)

Subjects:

The original gel image underlying Fig 5C blot results. by Te-Hsing Hsu (16973374)

The original gel image underlying Fig 5B blot results. by Te-Hsing Hsu (16973374)

S1 Data - by Sinthia Kabir Mumu (17705902)

Subjects: