Showing 17,781 - 17,800 results of 65,129 for search '(( 10 ((ng decrease) OR (mean decrease)) ) OR ( 50 ((nn decrease) OR (a decrease)) ))', query time: 1.01s Refine Results
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    Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

    Published 2021
    “…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI<sub>50</sub> of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”
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    Thin and thick slice perfusion maps. by Edwin Bennink (568194)

    Published 2015
    “…Scheme 2 (bilateral filtering, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137766#pone.0137766.t001" target="_blank">Table 1</a>) was used for processing this data. …”