A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <i>In Vivo</i> and Regulates Urethral Tension by Hiroshi Saga (584103)

“…</p><p>Smooth muscle contraction is a known to be promoted by lysophosphatidic acid. In this study, we showed that dosing rats with ONO-8430506 decreased intraurethral pressure accompanied by urethral relaxation. …”

Loss of Prox1a decreases PR production at 120 hours post-ablation. by Kellie Veen (17343374)

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

“…Among them, derivative <b>A11</b> had the most potent antiproliferative activity against A549 lung cancer cells (IC₅₀ = 0.009 μM) and was approximately 10-fold more potent than CuB, while the cytotoxicity of <b>A11</b> toward normal L02 cells was about 10-fold less potent, indicating a much wider therapeutic window than CuB. …”

Aggrecan knockdown ATDC5 chondroprogenitor cells have decreased Alcian blue staining and absorbance levels compared to control cells after ITS stimulation. by Juanita K. Hodax (6848540)

Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction by Jin Chai (183630)

“…</p><p>Conclusions</p><p>The levels of hepatic detoxification enzymes were significantly decreased in human obstructive cholestasis, and these decreases were positively associated with a marked reduction of FXR levels. …”

Decreased inflammatory markers of peritoneal macrophages following <i>in vivo</i> treatment with p30A peptide. by Jérôme Rambert (46851)

Decreased numbers of motor neurons in Tc1 and Dp(16)1Yey mice. by Sheona Watson-Scales (586942)

Graphs of marginal mean values of the studied parameters for dolphin kick, flutter kick and breaststroke kick with and without diving gear (Parameters that were not statistically d... by Marek Rejman (9199616)

Selection for West Nile virus populations with decreased susceptibility to ribavirin. by Greta A. Van Slyke (761322)

Coibamide A induces a time- and concentration-dependent decrease in plasma membrane integrity. by Andrew M. Hau (418935)

Percentage decreases in scores of self-reported health, large muscle function, and mobility by chronic diseases per wave after disease incidence. by James Davis (2267599)

24-hr treatment with 100nM M64HCl, 10μM PF573228, the combination of 100nM M64HCl and 10μM PF573228, 10μM PD98059, or the combination of 100nM M64HCl and 10μM PD98059 in migrating... by Sema Oncel (10152053)

Subjects:

24-hr treatment with 100nM M64HCl, 10μM PF573228, the combination of 100nM M64HCl and 10μM PF573228, 10μM PD98059, or the combination of 100nM M64HCl and 10μM PD98059 in migrating... by Sema Oncel (10152053)

Subjects:

Decreased biofilm formation in the Δ<i>tad123</i> mutant cells. by Tra-My Duong-Nu (7300970)

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…<p>(<b>A</b>) The expression levels of ER stress markers (P-PERK 0.6±0.1-fold, p<0.001, n = 5; PERK 0.7±0.1-fold, p = 0.00364, n = 5; P-IRE1α 0.6±0.0-fold, p<0.001, n = 5; IRE1α 0.6±0.1-fold, p<0.001, n = 5; GRP78 0.8±0.1-fold, p<0.001, n = 5; cleaved ATF6 0.1±0.0-fold, p<0.001, n = 5; spliced XBP1 0.3±0.0-fold, p<0.001, n = 5; 2 males and 3 females) are all decreased while the N-glycosylated VEGFR2 is increased (3.5±0.2-fold, p<0.001, n = 5) in HOX neonatal lungs at P10 indicating TUDCA can attenuate hyperoxia-induced ER stress. …”

Decrease of 4 Asp isomers at 70°C. by Kenzo Aki (386666)

“…<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058515#pone-0058515-g007" target="_blank">Figure 7a:</a> decrease of L-α-Asp with incubation of T6-Lα peptide at 70°C. …”

Chronic, sublethal neonicotinoid exposure decreases cumulative weight gain and cluster size of honey bee colonies. by Sarah C. Wood (4730634)

SCU decreases ischemia area, improves endothelium-dependent vasodilation and influence of PKG inhibitor in MIR rats. by Lin Li (28817)

Multiple miRNAs decrease telomerase activity. by Radmila Hrdličková (523455)

Rg3 decreases HDAC3 expression. by Xiu Shan (62157)