Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Yun Wu (150224)

“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC₅₀ = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”

Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Yun Wu (150224)

“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC₅₀ = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”

Changes in the total protein content and free amino acid profile in N stressed cells are consistent with a decrease in N assimilation. by Steve Dagenais Bellefeuille (654383)

Results of peptide toxicity of each diet. by Fatima Dikhanbayeva (11501962)

“…<p>Values are given as mean ± SD for a total of 50 animals. Control group (I) - 0.295 nm, Curd mass (II)– 0.122 nm, Curd mass with flaxseed flour (III)– 0.113 nm, curd mass with celery root powder (IV) - 0.114 nm, Curd mass with bee bread (V)– 0.127 nm. …”

<i>WNT10A</i>^–/–KO skin wound showing reduced fibrosis/fibrogenesis associated with the decreased expression of stromagenesis-related genes. by Ke-Yong Wang (234594)

A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere’s Disease—A Pilot Study by Tadashi Kitahara (702040)

“…<div><p>Meniere's disease, a common inner ear condition, has an incidence of 15–50 per 100,000. Because mental/physical stress and subsequent increase in the stress hormone vasopressin supposedly trigger Meniere's disease, we set a pilot study to seek new therapeutic interventions, namely management of vasopressin secretion, to treat this disease. …”

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric <i>in silico</i> ROCOCO trial by Daniëlle B. P. Eekers (5560430)

Large amounts of ingested phenylpyruvate are required to decrease the survival of adult <i>A. gambiae</i> mosquitoes. by Silke Fuchs (506300)

(a) Mycelial diameter (mm) determination on PDA plates, (b) Inhibition diameters, and (c) inhibition percentages of <i>Aspergillus flavus</i> treated with <i>U. epigea</i> extract... by Martha Cebile Jobe (21175426)

Table_4_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_2_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_1_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_3_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Reduction of IL-8 is associated with a relevant decrease of GBA2 expression in CF bronchial cells. by Nicoletta Loberto (2224150)

Treatment of CMT93 cells with IFNγ leads to a decrease in IRF-2 protein expression. by Michael S. Dicay (707490)

Intrathecal injection of mycolactone triggers a decrease of pro-inflammatory cytokines in spinal cord of Sham rats. by Caroline Isaac (4600654)

Quantitation of the decrease in viability of schistosomula caused by GSK343 treatment at different concentrations and incubation times. by Adriana S. A. Pereira (5900249)

Experimental protocol. by Hiroyuki Matsuta (13250169)

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Visualization of the primary motor network analyzed using FSL MELODIC. by Hiroyuki Matsuta (13250169)

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Fig 3 - by Hiroyuki Matsuta (13250169)

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