The capture efficiency of BioMagnetic solutions FerroSelect in PBS/1% BSA and whole blood showed a decrease in capture efficiency when moving to whole blood. by Peng Liu (120506)

Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Yun Wu (150224)

“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC₅₀ = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”

Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Yun Wu (150224)

“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC₅₀ = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”

<i>WNT10A</i>^–/–KO skin wound showing reduced fibrosis/fibrogenesis associated with the decreased expression of stromagenesis-related genes. by Ke-Yong Wang (234594)

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors by Alexandra Cousido-Siah (777034)

“…Among the three compounds, only MK204 can make a strong halogen bond with the protein (−4.4 kcal/mol, using QM calculations), while presenting the lowest desolvation cost among all the series, translated into the most selective and inhibitory potency AKR1B10 (IC₅₀ = 80 nM). …”

Top 10 pathways with the lowest p-value. by Rizka Fatriani (17485787)

“…Molecular docking results between PPARG and EP300 with the ten active compounds showed a binding affinity value of ≤ -5.0 kcal/mol in all dockings, indicating strong binding. …”

A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere’s Disease—A Pilot Study by Tadashi Kitahara (702040)

“…<div><p>Meniere's disease, a common inner ear condition, has an incidence of 15–50 per 100,000. Because mental/physical stress and subsequent increase in the stress hormone vasopressin supposedly trigger Meniere's disease, we set a pilot study to seek new therapeutic interventions, namely management of vasopressin secretion, to treat this disease. …”

Table_4_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_2_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_1_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Table_3_Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.xlsx by Xianping Li (3327297)

Treatment of CMT93 cells with IFNγ leads to a decrease in IRF-2 protein expression. by Michael S. Dicay (707490)

The long-term impact of sustained exposure-reducing interventions (represented by a decrease in density of female anophelines). by Azra C. Ghani (160248)

Quantitation of the decrease in viability of schistosomula caused by GSK343 treatment at different concentrations and incubation times. by Adriana S. A. Pereira (5900249)

S100A12 decreased SAA-induced ERK1/2 and MEK1/2 phosphorylation. by Yuen Ming Chung (406571)

Quantification of <i>ATP5B</i> mRNA and β-F1-ATPase protein expression shows decreased protein translation in obesity. by Lee Tran (2106961)

Progesterone decreased Henkel 100-induced responses in a dose-dependent manner in the OE of female mice. by Ninthujah Kanageswaran (683924)

“…(E) Relative reduction in peak response to Henkel 100 after progesterone preincubation at different concentrations (0.1 nM: 11.9 ± 2.1% (n = 3), 1 nM: 18.4 ± 3.1% (n = 3), 10 nM: 22.0 ± 11.4% (n = 4), 100 nM: 31.4 ± 7.3% (n = 4), 1 μM: 37.9 ± 2.2% (n = 4), and 10 μM: 48.8 ± 2.1% (n = 4)). …”

Propofol induced cell death and decreased mitochondrial membrane potential in a concentration- and time-dependent manner. by Chisato Sumi (3521705)

Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene by Muhammad Idrees (92773)

Table_1_Decreased Risk in the Pancreatic Cancer With History of Hay Fever: A Meta-Analysis.doc by Guannan Wang (2209297)

“…A history of hay fever was associated with a decreased risk of pancreatic cancer (OR, 0.57; 95% CI, 0.50–0.64, P < 0.00001) through fixed effect model.…”