Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Simulation results of dichromatic mirror across the 400 - 700 nm spectral range. by Ngoc-Hai Vu (22290844)

Synthesis and Characterization of New Organometallic Benzo[<i>b</i>]thiophene Derivatives with Potential Antitumor Properties by André P. Ferreira (2348185)

“…The benzo[<i>b</i>]thiophene derivative raloxifene is a selective estrogen receptor modulator (SERM) that has been found to decrease breast cancer risk in postmenopausal women compared to placebo. …”

High resolution structures visible with the 25 nm zone plate objective. by Kamal L. Nahas (13014698)

“…<p>139 CryoSXT tomograms were recorded from 107 cells using a 25 nm zone plate objective and several structures that were unrelated to HSV-1 infection were observed, including some that were not visible using the 40 nm zone plate objective. …”

The decrease in c-Myc protein levels in A549 cells was primarily due to proteasomal degradation. by Qin Li (36669)

Salience of authority-virtue phrases by year. by Daniel Hart (440152)

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

“…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC₅₀ = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC₅₀ of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC₅₀ of 65 and 126 nM, respectively). …”

Sensitivity analysis of 50:50 model. by Rachael Miller Neilan (10678614)

“…<p>A sensitivity analysis was conducted on the 50:50 model with constant 120 pA current to determine the sensitivity of pain output to select model parameters before injury (t = 10), during injury (t = 105), and after injury (t = 240). …”

Differences in gene expression between M and NM MCTs measured by RT-qPCR. by Kelly Bowlt Blacklock (6102878)

Dose response of airways to Methacholine shows a decreased contractility in <i>GSTCD</i>^-/- mouse lungs following LPS treatment. by Bo Liu (127343)

Required soil organic carbon content and maximum strain energy density as a function of normalized water content for clay contents of 16% and 50%. by Siul Ruiz (757454)

Synthesis and Spectroscopic Investigation of a Series of Push–Pull Boron Dipyrromethenes (BODIPYs) by Sunting Xuan (1494469)

“…All BODIPYs were nontoxic in the dark (IC₅₀ > 200 μM) and showed low phototoxicity (IC₅₀ > 100 μM, 1.5 J/cm²) toward human HEp2 cells. …”

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …”

Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis by Santiago Avila-Rios (3160959)

“…</p><p>Methods and Findings</p><p>We performed a systematic review of currently available publications on TDR in antiretroviral treatment-naïve adults in LAC. …”

MTT assay shows that the cells exposed to periostin siRNA showed a significant decrease in IC50 among the DDP, EPI, and DTX compared with the control siRNA group (control group) (<i>P</i><0.01). by Dongyang Xu (303547)

“…<p>MTT assay shows that the cells exposed to periostin siRNA showed a significant decrease in IC50 among the DDP, EPI, and DTX compared with the control siRNA group (control group) (<i>P</i><0.01).…”

Inverse Phase Transition in Droplet Clusters Levitating over the Locally Heated Water Layer by Alexander A. Fedorets (7376702)

“…Self-assembled microdroplet clusters can levitate above a locally heated water surface. Normally, the temperature of droplets is in the range of 50–95 °C. …”

Inverse Phase Transition in Droplet Clusters Levitating over the Locally Heated Water Layer by Alexander A. Fedorets (7376702)

“…Self-assembled microdroplet clusters can levitate above a locally heated water surface. Normally, the temperature of droplets is in the range of 50–95 °C. …”