Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

The effect of novel synthetic communities on plant shoot Pi content can be predicted by an NN. by Sur Herrera Paredes (674875)

“…The validation prediction error on NN is significantly smaller than LM (<i>p</i>-value = 5.25 × 10⁻¹⁰) and INT (<i>p</i>-value = 4.65 × 10⁻⁷). …”

Cardiac Contractility Structure-Activity Relationship and Ligand-Receptor Interactions; the Discovery Of Unique and Novel Molecular Switches in Myosuppressin Signaling by Megan Leander (459603)

“…Further, these motifs were present in red flour beetle, common water flea, honey bee, domestic silkworm, and termite MS-Rs. RhpMS and DrmMS decreased <i>R</i>. <i>prolixus</i> cardiac contractility dose dependently with EC₅₀ values of 140 nM and 50 nM. …”

Selective Inhibitors of Janus Kinase 3 Modify Responses to Lipopolysaccharides by Increasing the Interleukin-10-to-Tumor Necrosis Factor α Ratio by Julian Laux (13047767)

“…JAK1 is required for IL-10 receptor signaling, which suggests that, at exposure above the IC₅₀ (55 nM for tofacitinib on JAK1), there is less feedback control of TNFα levels. …”

IQG-607 decreases the infection of macrophages by <i>L</i>. <i>braziliensis</i> amastigotes. by Camila F. Amorim (676792)

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. by Maral Budak (6680351)

Dependence of absorbance at 510 nm associated with free available chloride on sulfuric acid concentration in sodium chlorite solution. by Ayuta Kishimoto (16814662)

Map of the study area, representing the 50 provinces, divided between the 6 different regions. by Jacopo Cerri (6271958)

Substitution of a lysine residue at position 8 of two model 9mer H2-K^b epitope precursors leads to a marked decrease of N-terminus trimming by ERAP1 <i>in vitro</i>. by Irini Evnouchidou (375919)

“…<p><i>Panels </i><i>A</i><i> and </i><i>B</i>, peptides LSIINFEKL and the variant LSIINFEAL (both at 50 µM) were incubated with 7.8 nM of ERAP1 for 1 hr at 37°C and the products analyzed by RP-HPLC. …”

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells by Tadeja Kuret (5059433)

“…<div><p>Serum amyloid A (SAA) is a sensitive inflammatory marker rapidly increased in response to infection, injury or trauma during the acute phase. …”

Chronic, sublethal neonicotinoid exposure decreases cumulative weight gain and cluster size of honey bee colonies. by Sarah C. Wood (4730634)

The loss of Sad kinases leads to a decrease in the number of neuronal progenitors in the cortex. by Pratibha Dhumale (5146484)

Hepcidin quantification by WCX-TOF MS in human samples that were pre-incubated with 0, 5 or 10 nM of PRS-080 to block binding of hepcidin to the WCX beads. by Coby M. M. Laarakkers (228091)

Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases by Xiao Li (107004)

“…In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC₅₀ = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC₅₀ = 18 ± 2 to 107 ± 6 nM). …”

Variation in the energy fluxes per CS and the density of RCs of leaves of Baijinpao and Kangnaixin under Al stress. by Jing Zhang (23775)

Prorocentin-5: A Cytotoxic Polyketide from the Benthic Marine Dinoflagellate <i>Prorocentrum lima</i> by Yunseok Choi (5625245)

Subjects:

Kif2a accumulation at the base of <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia causes instability. by Emily Bowie (543704)