Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D₂ by Nanae Nagata (3916574)

“…PGD₂ interacts with 2 types of G protein-coupled receptors, DP1 and DP2/CRTH2 (chemoattractant receptor homologous molecule expressed on T helper type 2 cells)/GPR44 to show a variety of biological effects. DP1 activation leads to Gs-mediated elevation of the intracellular cAMP level, whereas activation of DP2 decreases this level via the Gi pathway; and it also induces G protein-independent, arrestin-mediated cellular responses. …”

3‑Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer’s Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau I... by Yangjing Lv (21580685)

“…Compound <b>21d</b> emerged as a promising candidate, exhibiting potent and selective MAO-B inhibitory activity (IC₅₀ = 87.47 nM, SI > 229), as well as excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro<i>.…”

Epitope mapping using swapped DP2 mutants. by Nanae Nagata (3916574)

Decreased macrophage recruitment correlates with decreased angiogenesis. by Johanna R. Reed (306158)

“…<p>A) Quantification of BrdU incorporation demonstrates that decreased macrophage infiltration does not significantly correlate with a change in epithelial cell proliferation (N.S. = not significant). …”

Patterns of disease knowledge according to number of participants giving correct answers to each individual Chinese IBD-KID2 item, with vertical line representing 50% of the overal... by HaiQun Huang (20978503)

Nanomechanical analysis of Sup35NM. by Rubén Hervás (161905)

“…<p>Δ<i>L</i>_c (left) and <i>F</i> (right) histograms of pFS-2 polyproteins carrying Sup35NM. Like the wt proteins in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g003" target="_blank">Figures 3</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g004" target="_blank">4</a>, Sup35NM (first row) shows a broad polymorphism, including rare hM conformers. …”

Preclinical Evaluation of ¹³¹I/¹⁸F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging by Jianyang Fang (11301298)

Subjects:

Preclinical Evaluation of ¹³¹I/¹⁸F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging by Jianyang Fang (11301298)

Subjects:

How the variation in inhibitor concentration throughout one day affects the value of IC₅₀/(IC₅₀ + [R]) for different Abl1 inhibitors. by J. Roadnight Sheehan (20141887)

Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study by Mark Lown (3772432)

RhoA-induced suppression of the HSR decreases cell stress resistance and induces cell death via apoptosis. by Roelien A. M. Meijering (217816)

A decrease in CD44+ cells in response to hypoxia. by Daniel V. Brown (3797809)

Copper ion concentration (A, Control; B, strain A; C, strain B; D, strain F) of MSM during fermentation for <i>S</i>. <i>cerevisiae</i> strains in MSM with 0 (control) (A*, B*, F*)... by Xiang-yu Sun (748032)

Mycolactone induces a decrease in dermal collagen fibers. by José B. Gama (296675)

A frame from the final video containing human-hearable audio track showing grooming behavior and FM USV call at frame #50. by Piotr Popik (292215)

Decrease in cell migration and adhesion of MCF10A cells after knockdown of <i>MYO1C</i>. by Kittichate Visuttijai (3204519)

“…A dose-dependent decrease in relative cell index response to MYO1C depletion was observed reaching to a significant value with concentrations of 5 and 10 nM of <i>MYO1C</i>-siRNA at 48 hours post-transfection compared to control cells (mock transfection). …”

Germination percent response of <i>I</i>. <i>rugosum</i> as affected by decreasing osmotic potential (MPa) plotted over time (in days after sowing, DAS), modeled with the use of eq... by Charlemagne Alexander A. Lim (795608)

EphA4 immunostaining is decreased adjacent to injury site in ephrin-A5-Fc treated mice. by Yona Goldshmit (205708)

“…Arrows indicate lesion site. Scale bars in A–D, G,H, 100 µm; E,F, 50 µm.</p>…”

SUVmax and SUVmean for each hot sphere when the Gaussian filter is changed. by Masakazu Tsujimoto (22339504)

Subjects:

Western-blot analysis of RGC-5 cells exposed to UVB irradiation with or without the pretreatment of 10 µM CHC or 100 nM PACAP. by Huanhuan Cheng (640411)