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nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), mean decrease (Expand Search)
ns decrease » nn decrease (Expand Search), _ decrease (Expand Search), use decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), mean decrease (Expand Search)
ns decrease » nn decrease (Expand Search), _ decrease (Expand Search), use decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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721
Complete data.
Published 2024“…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”
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722
Fig 4 -
Published 2024“…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”
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723
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724
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725
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726
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727
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728
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729
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730
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731
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732
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733
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734
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735
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors
Published 2021“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido[4,5-<i>b</i>]indol-4-yl)(methyl)amino)piperidin-1-yl)propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”
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736
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors
Published 2021“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido[4,5-<i>b</i>]indol-4-yl)(methyl)amino)piperidin-1-yl)propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”
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737
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738
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739
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740