Showing 721 - 740 results of 80,257 for search '(( 10 ((nm decrease) OR (we decrease)) ) OR ( 50 ((ns decrease) OR (a decrease)) ))', query time: 0.69s Refine Results
  1. 721

    Complete data. by Jan Víteček (11434774)

    Published 2024
    “…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”
  2. 722

    Fig 4 - by Jan Víteček (11434774)

    Published 2024
    “…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”
  3. 723
  4. 724
  5. 725
  6. 726
  7. 727
  8. 728
  9. 729
  10. 730
  11. 731
  12. 732
  13. 733
  14. 734
  15. 735

    Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

    Published 2021
    “…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”
  16. 736

    Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

    Published 2021
    “…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC<sub>50</sub> value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”
  17. 737
  18. 738
  19. 739
  20. 740