Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the <em>Pea-comb</em> Mutation by Henrik Boije (115266)

“…The wild-type single-comb is reduced in size and distorted in the <em>Pea-comb</em> mutant. Pea-comb is formed by a lateral expansion of the central comb anlage into three ridges and is caused by a mutation in <em>SOX5</em>, which induces ectopic expression of the SOX5 transcription factor in mesenchyme under the developing comb. …”

Does wearing swimming goggles affect corneal morphology in keratoconic eyes? by Döndü Melek Ulusoy (5762939)

“…Results: The average values before and after wearing swimming goggles for 1, 10, and 20 min were 52.72 ± 5.36, 52.64 ± 5.52, 52.62 ± 5.38, and 52.22 ± 4.86, respectively (p=0.257). …”

Analysis of T cell apoptosis and functional immune responses in Mst1^−/− mice. by Konstantin V. Salojin (567844)

“…On day 14, serum samples were analyzed for OVA-specific IgG1 and IgG2a concentrations. Values and statistical significance are expressed as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098151#pone-0098151-g002" target="_blank">Fig. 2</a> and are representative of at least two independent experiments. …”

Comparison of ELK3 and miR-155 expression in uterine corpus endometrial carcinoma (UCEC). by E. Douglas Robertson (662431)

“…(A) Decreased levels of ELK3 in cancer (145) compared to normal (18) samples(fold change = 0.225, student t-test P-Value = 2.80028e-08). …”

Evolutionary relationships between the extended <i>MYH9</i> haplotypes. by Taras K. Oleksyk (53041)

“…The colors of the nodes indicate the 4-SNP E1-E5 haplotypes and shown in the same colors as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011474#pone-0011474-g001" target="_blank">Figure 1</a>. …”

Spatial regulation of platelet spreading. by Ashley Kita (200234)

“…Microstamps using this mold have protein stripes varying in width from 0.5 to 20 µm and separated by a constant 10 µm. The “10” is a fiduciary marker indicating the stamped protein micropattern width in micrometers. …”

Biological Responses to Perfluorododecanoic Acid Exposure in Rat Kidneys as Determined by Integrated Proteomic and Metabonomic Studies by Hongxia Zhang (164388)

“…Furthermore, the profiles of free amino acids in the PFDoA treated groups were investigated quantitatively by high-coverage quantitative iTRAQ-LC MS/MS, which showed levels of sarcosine, asparagine, histidine, 1-methylhistidine, Ile, Leu, Val, Trp, Tyr, Phe, Cys, and Met increased markedly in the 0.5 mg dosed group, while homocitrulline, α-aminoadipic acid, β-alanine, and cystathionine decreased.…”

Effect of sEH expression on subcellular localization. by Jonathan W. Nelson (2802394)

“…<p>(A) Primary neurons co-transfected with different amounts of GFP-sEH-WT plasmid. …”

Flavokawain B (FKB) down-regulates mRNA and protein expression of AR and AR target genes. by Xuesen Li (48046)

“…<p>(<b>A</b>).The protein expression of AR and PSA after indicated treatments for 16 hours or 5 µg/ml FKB for indicated period of times was analyzed by Western blot. α-Tubulin was detected as a loading control. …”

SCI alters the mRNA expression of canonical Wnt signalling components. by Carmen María Fernández-Martos (5649061)

“…<p>Expression of the canonical co-receptor <i>LRP5/6</i>, the downstream intracellular inhibitory transducer <i>GSK3-ß</i> and the <i>ß-catenin</i> transcription factor were quantified by qRT-PCR as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027000#pone-0027000-g001" target="_blank">Figure1</a>. …”

Dynamic profiles of the prototypic integrated system. by Jong Min Lee (271984)

“…<p>In (A), the concentration of carbon and amount of biomass within the cellular system over a simulation time of 10 h is illustrated. …”

The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription-3 by Chiara Vardabasso (88636)

“…HeLa cells were transfected with a specific siRNA against hNAP-1 or a control siRNA, and then transfected with the LTR-luciferase reporter together with Tat (5 and 25 ng). …”

Bay-11-7082 inhibits NF-κB binding to DNA in breast cancer cells. by Shannon M. Smith (115335)

“…<p>Breast cancer cells, MDA-MB-231 (<b>A–C</b>) and SUM159 (<b>D–F</b>), were treated with either a DMSO control or Bay-11-7082 at different concentrations (0.625 µM - 5.0 µM) for 24, 48 or 72 hrs. …”

SMF-3::GFP is down-regulated upon Mn exposure. by Catherine Au (242983)

“…C, SMF-3::GFP signal is strongly decreased at 5 hours post-treatment. After a day of recovery, SMF-3::GFP expression returns to control levels and SMF-3::GFP relocates to the apical plasma membrane (D). …”

Model suggests plausible scenarios for Hsp72 regulation require both reduction of p65 and IKK inhibition. by Patrick W. Sheppard (586664)

“…The model with reduced p65 protein and interactions upstream (US, increasing inactivation rate <i>kiA20</i> 10-fold) and downstream (DS, simulated by decreasing IκBα phosphorylation rate, <i>kc2a</i>, by 6-fold) also match many qualitative features of the model. …”

Proposed model of how WSSV-induced glutamate-driven anaplerosis is regulated by the mTORC2 at 12 hpi. by Chun-Yuan Li (577449)

“…[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146902#pone.0146902.ref005" target="_blank">5</a>]. …”

Data Sheet 1_Cytokine profile, differential somatic cell count, and oxidative status of Italian Mediterranean buffalo milk affected by the temperature–humidity index.docx by Maria Giovanna Ciliberti (10718484)

“…The level of IL-4 was higher in the THI ≥ 76 class than in the ≤72 to <76 range. Data on DCC showed a decrease in the percentage of macrophages and lymphocytes as the THI increased from the ≤72 to <76 range to THI ≥ 76. …”

Standardized mean effect differences between wet-lab experiment and model simulations. by Rachael Miller Neilan (10678614)

“…Positive Hedges’ <i>g</i> is indicative of an increase in pain-like effect for the indicated comparison and a negative Hedges’ <i>g</i> is indicative of a decrease in pain-like effects. …”

Table_1_Marine sediment nitrogen isotopes and their implications for the nitrogen cycle in the sulfate-methane transition zone.xlsx by Xin Yang (104842)

“…In the SMTZ, the NH4+ concentration decreases, the δ15NTN shows a negative excursion, δ15Ndecarb displays a positive excursion.…”

Non-invasive imaging of PIK3CA promoter modulation in tumor xenografts of living mice after cisplatin treatment. by Snehal M. Gaikwad (279479)

“…The bioluminescence signal in the control mice (n = 3) increased with time while that of the treated group (n = 4) showed a slight decrease at 11th day after first treatment and significant attenuation at 15^th day after second treatment (p<0.025). 3b2. …”