Image_2.TIF by Cong He (5074154)

“…This study established the HFD animal model to determine the impact of HFD on the gastric microbiota and its relationship with the alterations of gut microbiota. A total of 40 male C57BL/6 mice were randomly allocated to receive a standard chow diet (CD) or HFD for 12 weeks (12CD group and 12HFD group) and 24 weeks (24CD group and 24HFD group) (n = 10 mice per group). …”

Functional enrichment of protein subnetworks in HIV-1 producer cells after co-culture with uninfected cells. by James W. Bruce (10204626)

“…<p>Prize-Collecting Steiner Forest (PCSF) analysis was used to generate subnetworks from proteins with significant changes after 5 or 60 minutes of co-culture. The top 30 enriched Gene Ontology (GO) biological process terms from both 5 min and 60 min subnetworks were divided into those that primarily exhibited (A) early or (B) late enrichment after co-culture. …”

Effect of PPi on ΔΨm during near-anoxia in cultured rat neonatal cells. by Junko Shibayama (387144)

“…<p><b>A–C</b>. Control. ΔΨm-dependent signal gradually decreased throughout 10 min of anoxia. …”

Distance changes associated with the wing-tissue contraction pulses and autofluorescence intensity. by Masaki Iwata (525821)

“…These are static images from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089500#pone.0089500.s003" target="_blank">Movie S3</a>. …”

Simulation of OKR adaptation. by Tadashi Yamazaki (40072)

“…Gain ratio was defined by the modulation of a VN neuron at each 10 cycles divided by the modulation at the 1^st cycle. …”

Disease symptoms are negatively correlated with PCD in <i>Botrytis</i>. by Neta Shlezinger (209649)

“…Leaves of <i>A. thaliana</i> Col-0 plants were inoculated with a spore suspension of <i>B. cinerea</i> B05.10. …”

Data_Sheet_2_Molecular Mechanisms Underlying the Acclimation of Chlamydomonas reinhardtii Against Nitric Oxide Stress.xlsx by Eva YuHua Kuo (8955614)

“…<p>The acclimation mechanism of Chlamydomonas reinhardtii to nitric oxide (NO) was studied by exposure to S-nitroso-N-acetylpenicillamine (SNAP), a NO donor. Treatment with 0.1 or 0.3 mM SNAP transiently inhibited photosynthesis within 1 h, followed by a recovery, while 1.0 mM SNAP treatment caused irreversible photosynthesis inhibition and mortality. …”

Data_Sheet_1_Molecular Mechanisms Underlying the Acclimation of Chlamydomonas reinhardtii Against Nitric Oxide Stress.PDF by Eva YuHua Kuo (8955614)

“…<p>The acclimation mechanism of Chlamydomonas reinhardtii to nitric oxide (NO) was studied by exposure to S-nitroso-N-acetylpenicillamine (SNAP), a NO donor. Treatment with 0.1 or 0.3 mM SNAP transiently inhibited photosynthesis within 1 h, followed by a recovery, while 1.0 mM SNAP treatment caused irreversible photosynthesis inhibition and mortality. …”

Loss of Sirt3 abolished BMC-mediated cardiac repair in post-MI mice. by Heng Zeng (324703)

“…Treatment with BMCs significantly increased ESP whereas treatment of post-MI mice with Sirt3KO-BMC had little effects on ESV and ESP. n = 5–7 mice, *p<0.05. <b>F</b>. BMC therapy led to a significant improvement of maximum +dP/dt and minimum -dP/dt pressures compared to control post-MI mice. …”

Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication by Annie Guérin (215559)

“…Among combination therapy users, the probability of patients using a combination with a CYP2C19 inhibitor decreased by 53% (OR = 0.47; <i>p</i><0.001); however, 31.5% of patients were still prescribed a clopidogrel-PPI combination therapy. …”

Data Sheet 1_The effect of mepolizumab dosage form on treatment outcomes in severe asthma.pdf by Martina Vetchá (21143222)

“…</p>Results<p>Three months after initiation of administration, all methods showed improvement compared to the values at the beginning of treatment, with ER decreasing from a median of 4 to 0. Similarly, the median OCS decreased from 5 mg to 0 mg across all methods throughout the treatment. …”

Supplementary Material for: AST-120 to target protein-bound uremic toxins improves cardiac output and kidney oxygenation in experimental chronic kidney disease. by Sivertsson E. (14625689)

“…Methods In rats, the right kidney and 2/3 of the left kidney were surgically removed (5/6 nephrectomy). Animals were fed a normal salt diet and randomized to either no treatment (control) or chronic treatment with either the oral absorbent AST-120 to reduce plasma levels of protein bound uremic toxins; or the ACEI enalapril to inhibit angiotensin II signaling for five weeks. …”

FGFR1-Frs2/3 pathway is required for the specification of prosensory domain. by Kazuya Ono (513633)

“…<p>(A–C) p27^Kip1 (magenta) is expressed in the post-mitotic, BrdU (green) negative, prosensory domain (bracket) in sections of E14.5 cochlea (A). …”

Supplementary Material for: Elderly Patients with Moderate-To-Severe Ulcerative Colitis Are More Likely to Have Treatment Failure and Adverse Outcome by Zhang M. (3218208)

“…A decreased level of clinical activity index (2.0 [−1.5 to 4.00] vs. 6.0 [3.0–8.0], <i>p</i> < 0.001), reduction of C-reactive protein (23.9 [3.5–65.5] vs. 27.8 [9.7–58.1] mg/L), and erythrocyte sedimentation rate (9.0 [−1.3 to 30.5] vs. 15.5 [3.8–36.5] mm/h) at 4 weeks after steroid induction was less obvious in the elderly. …”

Embryonic <i>Cul4b</i> is important for epiblast growth and location of primitive streak layer cells by Chun-Yu Chen (486495)

“…Second, we observed that <i>Mash2</i>-expressing cells were present in the extraembryonic tissues of <i>Cul4b-</i>deficient embryos at E6.5 but were absent at E7.5. In addition, the loss of <i>Cul4b</i> resulted in decreased expression of cyclin proteins, which are required for the cell cycle transition from G1 to S. …”

Data Sheet 1_Physicochemical property and microbial community characteristics of the casing soil for cultivating Oudemansiella raphanipes.pdf by Jinjia Liu (2819824)

“…</p>Methods<p>In this study, soil enzyme activity, physicochemical properties, and microorganisms at five cultivation stages [namely casing (A1), mycelial (A2), primordial (A3), fruiting (A4), and harvesting (A5)] of O. raphanipes cultivation were evaluated in casing soils.…”

Neuronal AID of LET-363/mTOR extends lifespan without impairing growth. by Hannah J. Smith (17002216)

“…Full statistics in <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010938#pgen.1010938.s008" target="_blank">S8 Fig</a></b>.…”

Visualization of pathways, interacting network, and validation of selected downstream regulators. by Soumya Panigrahi (188599)

“…For CrkL, apoptin induced inhibition of Bcr-Abl phosphorylation lead to the down-regulation of CrkL resulting in lower phosphorytion indicating that apoptin decreases the activation of CrkL, a down-stream substrate of Bcr-Abl. …”

The expression of α7^GFP by cells in the mesenchyme and the impact of α7-cell lineage ablation on tooth organ ectodermal patterning. by Scott W. Rogers (271631)

“…Macrophages identified by IBA1 are present and even abundant at this stage, but they do not express either α7^GFP or EDAR after E15.5 (not shown). <b>C</b>) Conditional ablation of mesenchyme cells expressing α7^Cre using the Rosa26-LoxP(DTA) strategy described in the text and previously <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036467#pone.0036467-Rogers1" target="_blank">[16]</a> results in abnormal tooth patterning. …”

Image2.TIF by Sandy Koenig (4974728)

“…Furthermore, in the young rats, incubation with IL-6 and IL-10 antibodies before LPS-stimulation led to a robust decrease of IL-6 production and an increase of TNFα production by the pituitary cells. …”