Image_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Small-metabolite inhibitors of mGPDH are not selective. by Adam L. Orr (526725)

“…Data are means ± S.E. (n = 3). <i>GAP</i>, glyceraldehyde 3-phosphate; <i>Glu</i>, glutamate; <i>Mal</i>, malate; <i>Suc</i>, succinate; <i>Rot</i>, rotenone; <i>GP</i>, glycerol phosphate; <i>AtA5</i>, atpenin A5. …”

Wild inside: Urban wild boar select natural, not anthropogenic food resources by Milena Stillfried (3201564)

“…We categorized the WB into five stomach content categories but found no significant difference in the frequency of those categories between urban and rural WB. …”

Inhibition of sustained and initial actin polymerization prevents ACh-induced sustained and initial smooth muscle contraction in muscle cells. by Sunila Mahavadi (325262)

“…<p>Muscle contraction was measured by scanning micrometry. <i>A</i>: Pre-treatment of dispersed smooth muscle cells with the MLCK inhibitor ML-9 (10 μM, 10 min), RhoA inhibitor <i>Clostridium botulinum</i> C3 exoenzyme (2μg/ml, 1 h), Rho kinase inhibitor Y27632 (10 μM, 10 min), FAK inhibitor PF573228 (10 μM, 1 h) or Arp2/3 inhibitor CK-666 (200 μM, 1h), actin polymerization inhibitors (cytochalasin D, 10 μM; latrunculin, 1 μM, 1 h) was followed by 1 μM ACh for 10 min. …”

MAGLi 432 treatment after LPS challenge does not reduce BBB permeability and inflammatory cytokine expression in the cortex. by Alicia M. Kemble (8555517)

“…<p><b>(A)</b> Immunofluorescence micrographs of 100-μm cortical sections from mice (n = 6) injected with 70-kDa FITC-dextran following LPS challenge and treatment (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0268590#pone.0268590.g003" target="_blank">Fig 3A</a></b>) stained with an anti-CD31 (PECAM-1) antibody (orange) to label blood vessels and DAPI as a nuclear stain (blue). …”

Data_Sheet_1_Oral Vaccination Reduces the Effects of Lawsonia intracellularis Challenge on the Swine Small and Large Intestine Microbiome.pdf by Fernando L. Leite (5690174)

“…Vaccination altered both small and large intestine microbiome community structure and led to a significant 3.03 log₁₀ reduction in the amount of L. intracellularis shed by the challenged pigs. …”

Image_1_Prognostic value of blood pressure and resting heart rate in patients with tricuspid regurgitation.JPEG by Shuai Guo (1353816)

“…</p>Results<p>The cohort had 45.9% male patients and a mean age of 62.5 ± 15.9 years. At the 2-year follow-up, 165 patient deaths had occurred. …”

Table_1_Prognostic value of blood pressure and resting heart rate in patients with tricuspid regurgitation.docx by Shuai Guo (1353816)

“…</p>Results<p>The cohort had 45.9% male patients and a mean age of 62.5 ± 15.9 years. At the 2-year follow-up, 165 patient deaths had occurred. …”

Table_2_Prognostic value of blood pressure and resting heart rate in patients with tricuspid regurgitation.XLSX by Shuai Guo (1353816)

“…</p>Results<p>The cohort had 45.9% male patients and a mean age of 62.5 ± 15.9 years. At the 2-year follow-up, 165 patient deaths had occurred. …”

Data_Sheet_1_Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome.pdf by Min-Su Kim (183958)

“…Functional assessments performed between D20-D23 revealed that MYH6-R443P variant CMs contracted more slowly (40 ± 2 vs. 47 ± 2 contractions/min, P < 0.05), shortened less (5.6 ± 0.5 vs. 8.1 ± 0.7% of cell length, P < 0.05), and exhibited slower shortening rates (19.9 ± 1.7 vs. 28.1 ± 2.5 μm/s, P < 0.05) and relaxation rates (11.0 ± 0.9 vs. 19.7 ± 2.0 μm/s, P < 0.05). …”

Hippocampal Bdnf and pAkt protein expression. by Itsuki Kageyama (12889998)

“…Hippocampal Bdnf and pAkt protein levels were decreased in the Period I with HFCS. Period I: C, n = 5; H, n = 6 (Bdnf), C and H, n = 6 (pAkt), Period II: C and H, n = 8 (Bdnf), C and H, n = 8 (pAkt), Period III: C and H, n = 7 (Bdnf), C and H, n = 6 (pAkt). …”

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK... by Yapeng Li (124282)

“…Administration of fasudil at 10 mg/Kg significantly attenuated ROCK activation during reperfusion and resulted in an improved SERCA activity which was closely associated with decreases in temporal activation of ER stress and IS changes. …”

Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during <i>in vitro</i> cardiogenesis by Junichiro Miake (4373017)

“…Therefore, in the present study, we investigated the expression patterns and functional roles of the <i>Cited4</i> gene during <i>in vitro</i> cardiogenesis. …”

Image_2_Effect of β-Hydroxybutyrate on Autophagy Dynamics During Severe Hypoglycemia and the Hypoglycemic Coma.TIF by Carmen Torres-Esquivel (9408707)

“…Here, we aimed to investigate autophagy dynamics in the brain of rats subjected to severe hypoglycemia (SH) without glucose infusion (GI), severe hypoglycemia followed by GI (SH + GI), and a brief period of hypoglycemic coma followed by GI (Coma). …”

Image_1_Effect of β-Hydroxybutyrate on Autophagy Dynamics During Severe Hypoglycemia and the Hypoglycemic Coma.TIF by Carmen Torres-Esquivel (9408707)

“…Here, we aimed to investigate autophagy dynamics in the brain of rats subjected to severe hypoglycemia (SH) without glucose infusion (GI), severe hypoglycemia followed by GI (SH + GI), and a brief period of hypoglycemic coma followed by GI (Coma). …”

Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize <i>Staphylococcus aureus </i>Quorum-Sensing by Bradley O. Elmore (282347)

“…Therefore, we hypothesized that apoB48 would be sufficient to antagonize <i>S</i>. …”

Data_Sheet_1_Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing.docx by Katja Saldeitis (11111214)

“…Specifically, we found a decreased gain of best-frequency input in thalamocortical (TC)-recipient input layers that correlated with the relative lesion of layer VI neurons, but not layer V neurons. …”

Early Onset Pre-Eclampsia Is Associated with Altered DNA Methylation of Cortisol-Signalling and Steroidogenic Genes in the Placenta by Kirsten Hogg (283182)

“…Significant hypomethylation was observed in pre-eclampsia but not nIUGR placentae for steroidogenic genes, including <i>CYP11A1</i> (exon1; EOPET; −9.66%; <i>P</i><0.00001, and LOPET; −5.77%; <i>P</i><0.001), 3β-hydroxy-delta-5-steroid dehydrogenase type 1 (<i>HSD3B1</i> exon 2; EOPET; −12.49%; <i>P</i><0.00001, and LOPET; −6.88%; <i>P</i><0.001), TEA domain family member 3 (<i>TEAD3</i> intron 1; EOPET; −12.56%; <i>P</i><0.00001) and <i>CYP19</i> (placental-specific exon 1.1 promoter; EOPET; −10.62%, <i>P</i><0.0001). …”

Data Sheet 1_Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.zip by Na Wang (193263)

“…FMN supplementation at 0.5 μM enhanced the rate of first polar body extrusion and blastocyst formation post parthenogenetic activation. …”