Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…In an effort to increase OR and decrease AR affinity by structure activity analysis of this series, antagonist activity at κ-(K)­OR appeared in 5′-esters (ethyl <b>24</b> and propyl <b>30</b>), which retained TSPO interaction (μM). 7-Deaza modification of C2-(arylethynyl)-5′-esters but not 4′-truncation enhanced KOR affinity (MRS7299 <b>28</b> and <b>29</b>, <i>K</i>_i ≈ 40 nM), revealed μ-OR and DOR binding, and reduced AR affinity. …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…In an effort to increase OR and decrease AR affinity by structure activity analysis of this series, antagonist activity at κ-(K)­OR appeared in 5′-esters (ethyl <b>24</b> and propyl <b>30</b>), which retained TSPO interaction (μM). 7-Deaza modification of C2-(arylethynyl)-5′-esters but not 4′-truncation enhanced KOR affinity (MRS7299 <b>28</b> and <b>29</b>, <i>K</i>_i ≈ 40 nM), revealed μ-OR and DOR binding, and reduced AR affinity. …”

Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice by Cristina Sastre (503532)

“…Hyperlipidemia accelerates the progression of renal damage, but the mechanisms of the deleterious effects of hyperlipidemia remain unclear.</p><p>Methods</p><p>We evaluated whether hyperlipidemia modulates Klotho expression in kidneys from C57BL/6 and hyperlipidemic apolipoprotein E knockout (ApoE KO) mice fed with a normal chow diet (ND) or a Western-type high cholesterol-fat diet (HC) for 5 to 10 weeks, respectively.…”

Table_5_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

FEF inactivation decreased ipsilesional and contralesional microsaccade peak velocities, both before and after cue onset. by Tyler R. Peel (2935848)

“…<p>(<b>A</b>) Unilateral (left) FEF inactivation reduced peak velocity for contralesional microsaccades independently of amplitude in our example monkey DZ and also decreased peak velocities for ipsilesional microsaccades. …”

Image_5_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF by Yung-Yu Yang (9343376)

“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”

Supplementary Material for: Clinical Implications of Decreased Computed Tomography Value after Ramucirumab in Advanced Gastric Cancer by Izawa N. (6834062)

“…<b><i>Objectives:</i></b> This study aimed to evaluate whether a decrease of computed tomography (CT) value for tumors serves as a predictive marker in patients with advanced gastric cancer (aGC) who have undergone chemotherapy with vascular epithelial growth factor receptor 2 inhibitor (ramucirumab). …”

Supplementary Material for: Enhanced Recovery after Surgery for Radical Cystectomy Decreases Postoperative Complications at Different Times by Lannes F. (11465377)

“…<b><i>Results:</i></b> A total of 150 patients underwent radical cystectomy, 74 without ERAS and 76 with ERAS protocol. …”

Filamentation induced by DTPA is associated with a decrease in Nrg1 protein level, and requires the cAMP-PKA pathway and the kinase Sok1. by Elizabeth J. Polvi (3163500)

Table_1_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.docx by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_3_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_1_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_2_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Gap junction (GJ) communication decreases the proportion of cells exhibiting Ca²⁺ spikes. by Dharsan K. Soundarrajan (11632145)

Image_2_EEG 40 Hz Coherence Decreases in REM Sleep and Ketamine Model of Psychosis.TIF by Santiago Castro-Zaballa (6238823)

“…Basal recordings were obtained and ketamine (5, 10, and 15 mg/kg, i.m.) was administrated. Gamma activity (power and coherence) was analyzed in the abovementioned conditions. …”

Image_1_EEG 40 Hz Coherence Decreases in REM Sleep and Ketamine Model of Psychosis.TIF by Santiago Castro-Zaballa (6238823)

“…Basal recordings were obtained and ketamine (5, 10, and 15 mg/kg, i.m.) was administrated. Gamma activity (power and coherence) was analyzed in the abovementioned conditions. …”

Data_Sheet_1_Risk of psychological distress by decrease in economic activity, gender, and age due to COVID-19: A multinational study.PDF by Minji Kim (1722313)

“…Moreover, countries with lower HDI showed a higher prevalence of decrease in economic activity, especially at lower education levels.…”

Adding tsetse control to medical activities contributes to decreasing transmission of sleeping sickness in the Mandoul focus (Chad) by Mahamat Hissene Mahamat (4282306)

“…Pre-2014, control of HAT relied solely on case detection and treatment, which lead to a gradual decrease in the number of cases of HAT due to annual screening of the population.…”

Associations between genetic ancestry (per 10% greater proportion of BGA) and BMI, WHR and PBF (N = 1726). by Sunali D. Goonesekera (721083)

Length-Dependent Convergence and Saturation Behavior of Electrochemical, Linear Optical, Quadratic Nonlinear Optical, and Cubic Nonlinear Optical Properties of Dipolar Alkynylruthe... by Bandar Babgi (2360545)

“…The syntheses of <i>trans</i>-[Ru{4,4′-CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppm)₂] (<b>19</b>), <i>trans</i>-[Ru{4,4′,4′′-CCC₆H₄CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppm)₂] (<b>20</b>), <i>trans</i>-[Ru{4,4′,4′′,4′′′-CCC₆H₄CCC₆H₂[2,5-(OEt)₂]CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppe)₂] (<b>21</b>), <i>trans</i>-[Ru{4,4′,4′′,4′′′-CCC₆H₄CCC₆H₂[2,5-(OEt)₂]CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppm)₂] (<b>22</b>), <i>trans</i>-[Ru{4,4′,4′′,4′′′-CCC₆H₄CCC₆H₄CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppm)₂] (<b>23</b>), and <i>trans</i>-[Ru{4,4′,4′′,4′′′,4′′′′-CCC₆H₄CCC₆H₄CCC₆H₂[2,5-(OEt)₂]CCC₆H₂[2,5-(OEt)₂]CCC₆H₄NO₂}Cl(dppm)₂] (<b>24</b>) are reported, together with those of precursor alkynes, complexes with the donor−π-bridge−acceptor formulation that affords efficient quadratic and cubic NLO compounds; the identity of <b>19</b> was confirmed by a structural study. …”