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A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications
Published 2017“…Lumefantrine concentrations were also influenced by ABCB1 variants in the presence of nevirapine. The most critical pharmacogenetic consideration identified was the association of glucose-6-phosphate dehydrogenase deficiency with development of hemolytic anemia and decreased hemoglobin levels in patients treated with primaquine or a combination of chlorproguanil-dapsone-artesunate. …”
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285
Effects of Climate and Atmospheric Nitrogen Deposition on Early to Mid-Term Stage Litter Decomposition Across Biomes
Published 2021“…In contrast, expected changes in atmospheric N deposition will decrease the mid-term mass loss of high-quality litter by 1.4-2.2% and that of low-quality litter by 0.9-1.5% in the temperate biome. …”
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286
Qatar Culture Collection of Microalgae: A Sustainable Source for Biodiesel Production and Omega Fatty Acid Compounds
Published 2016“…In addition, we observed the presence of the omega-3 and 9 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic (EPA, 20:5 n-3), docosahexaenoic (DHA, 22:6 n-3) and Nervonic Acid (C24:1 n-9) acids, which have a high commercial value and are known for their beneficial effects on human health…”
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287
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
Published 2024“…Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. …”
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288
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
Published 2024“…Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. …”
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Flight Scheduling in the Airspace
Published 2016“…The tests were conducted under a Windows 7 machine with an Intel Core i7 and 8 GB of RAM. The model was tested on each instance with 1 hour time limit. …”
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291
Development of pH-Controlled Aluminum-Based Polymeric Gel for Conformance Control in Sour Gas Reservoirs
Published 2020“…PAM/AlAc system has a gelation time of around 50 min at 75 °C making it suitable for near-wellbore treatments, while the gelation time increased to 80 min upon increasing the pH of the system from 4.1 to 4.6. Moreover, the system showed good stability in saline conditions with NaCl concentration of up to 50,000 ppm. …”
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Impact of the COVID-19 lockdown on lifestyle behaviors and their association with personality among adults in Qatar: A cross-sectional study
Published 2022“…The overall MD adherence decreased during lockdown (5.9 vs. 6.1, p < 0.001). …”
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Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines
Published 2016“…The pH range for the Clinoleic formulations (7.1–7.5) was slightly higher than that of the Intralipid formulations (6.5–6.9). …”
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Gas Driven Fracture during Gas Production using HeleShaw Cell
Published 2018“…The gap between the two sheets is maintained using filter sheets that have a thickness of 1/16 in. (1.6 mm) at the boundaries. Fluids flow radially between the sheets through a port in the middle of the bottom sheet. …”
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Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
Published 2020“…Compared with control, we found in STZ-rats with established pain hypersensitivity (5 weeks post-STZ) several significant changes including: (a) A 23% increase in the incidence of spontaneous activity (SA) in Aβ-LTMs (but not C-mechanosensitive nociceptors) that may cause dysesthesias/paresthesia suffered by DPNP patients, (b) membrane hyperpolarization and a ∼85% reduction in SA rate in Aβ-LTMs by K7 channel activation with retigabine (6 mg/kg, i.v.) suggesting that K7/M channels may be involved in mechanisms of SA generation in Aβ-LTMs, (c) decreases in AP duration and in duration and amplitude of afterhyperpolarization (AHP) in C-and/or Aβ-nociceptors. …”
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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
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Simulation and Optimization of an LNG Plant Cold Section
Published 2018“…Using the short cut method, optimization revealed that optimized MR composition resulted in almost 10% MR compression power and 6% plant operating cost savings, whereas new intermediate propane evaporation pressures, identified using detailed simulation, and flowrates decreased the propane compression power and operating costs by around 3.6%, and 2%, respectively. …”
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Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines
Published 2016“…The pH range for the Clinoleic formulations (7.1–7.5) was slightly higher than that of the Intralipid formulations (6.5–6.9). …”
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