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1261
Sulforaphane reduces obesity by reversing leptin resistance.
Published 2022“…Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia. …”
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1262
Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c...
Published 2024“…Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search for bioactives from natural sources as alternative or complementary modalities to synthetic medicines; especially for cancer treatment, which incidence and mortality rates are on the rise worldwide. …”
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1263
Nickel Toxicity Interferes with NO3−/NH4+ Uptake and Nitrogen Metabolic Enzyme Activity in Rice (Oryza sativa L.)
Published 2022“…A Ni concentration of 200 µM significantly decreased the NO3− concentration in rice leaves, as well as the activities of nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS), and glutamate synthetase (GOGAT), respectively, when compared to the control. …”
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1264
In silico and in vivo models for Qatari-Specific classical homocystinuria as basis for development of novel therapies.
Published 2018“…Wildtype CBS, but not the p.R336C mutant, was able to restore the yeast growth in ΔCBS deficient yeast in a complementation assay. The p.R336C knock-in HEK293T and HepG2 cells decreased the level of CBS expression and reduce its structural stability; however, treatment of the p.R336C knock-in HEK293T cells with betaine, a chemical chaperone, restored the stability and tetrameric conformation of CBS, but not its activity. …”
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1265
Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model.
Published 2019“…Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen (H₂RGOTi)-reduced graphene oxide/TiO₂ semiconductor photocatalysts recently employed in AOPs. …”
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1266
Dietary Intake Is Not Associated with Body Composition nor with Biochemical Tests but with Psychological Status of Cancer Patients Receiving Chemotherapy
Published 2023“…Each participant completed a reliable validated questionnaire, psychological questionnaire, quality of life questionnaire, and three-day food records. …”
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1267
Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
Published 2017“…Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would mitigate AGEs formation via activating the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway in a mouse model of high fat diet-induced obesity. …”
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1268
Cyclic voltammetry and XPS studies of poly (aniline-co-3-aminophenol)
Published 2022“…In the present work, we prepared enormously soluble poly (aniline-co-3-aminophenol) (PA-co-3-AP) copolymers via a simple chemical oxidative method with aniline and 3-aminophenol, and their properties are compared with conventional polyaniline (PA). …”
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1269
Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.
Published 2021“…We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97) women recruited to a PCOS biobank. …”
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1270
Adaptative Network Topology for Data Centers
Published 2016“…Motivated by these challenges, we propose a new data center architecture, called VacoNet that combines the advantages of previous architectures while avoiding their limitations. …”
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1271
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Published 2020“…To mimic hypertension, the rat portal vein (RPV) was mechanically stretched, and the protective effects of APN on mechanical stretch-induced vascular remodeling and the molecular mechanisms involved were examined by using 10μg/ml APN. Mechanically stretching the RPV significantly decreased APN protein expression after 24 hours and APN mRNA expression in a time-dependent manner in VSMCs. …”
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1272
Tailoring the defects of sub-100 nm multipodal titanium nitride/oxynitride nanotubes for efficient water splitting performance
Published 2021“…Deciphering the photocatalytic-defect relationship of photoanodes can pave the way towards the rational design for high-performance solar energy conversion. Herein, we rationally designed uniform and aligned ultrathin sub-100 nm multipodal titanium nitride/oxynitride nanotubes (TiONxNTs) (x = 2, 4, and 6 h) via the anodic oxidation of Ti-foil in a formamide-based electrolyte followed by annealing under ammonia gas for different durations. …”
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1273
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1274
Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
Published 2018“…Angiotensin II (Ang II) amplifies TGF-β1 activation in the VSMCs of the arterial wall with aging. In this study, we hypothesized that a reduced expression of the protein vasorin plays a contributory role in magnifying Ang II-associated fibrogenic signaling in the VSMCs of the arterial wall with aging. …”
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1275
Synthesis of silica supported ni and cu catalyst for carbon dioxide methanation reaction
Published 2019“…In this study we investigate the synthesis of nickel and copper catalyst supported on silica for CO2 conversion to methane. …”
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1276
Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats
Published 2016“…In study 4, AF43136 at 10 mg/kg decreased infarct size, similarly to the positive control CsA compared to the appropriate vehicle (39.4 ± 5.9% vs. 58.1 ± 5.4% and 45.9 ± 2.4% vs. 63.8 ± 4.1%, p < 0.05, respectively). …”
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1277
Western and ketogenic diets in neurological disorders: can you tell the difference?
Published 2022“…Here, we discuss the principles of brain metabolism with a focus on the distinct effects of the Western and ketogenic diets on the progression of neurological diseases such as epilepsy, Parkinson's disease, Alzheimer's disease, and traumatic brain injury, highlighting the need to further explore the potential therapeutic effects of the ketogenic diet and the importance of standardizing dietary formulations to assure the reproducibility of clinical trials.…”
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1278
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1279
New genetic insights into improving barley cope with salt stress via regulating mineral accumulation, cellular ion homeostasis, and membrane trafficking
Published 2023“…This study was designed to explore the natural variation of responsive physiological and agronomic traits in a diverse spring barley panel under salt-affected soil and the application of selenium nanoparticles (Se-NP) during the vegetative phase. …”
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1280
Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
Published 2021“…Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic conditions. …”
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