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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic...
Published 2021“…Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. In clinical chemotherapy of breast cancer, increased expression of Glo1 was associated with decreased patient survival, with hazard ratio (HR) = 1.82 (logrank p < 0.001, n = 683) where upper quartile survival of patients was decreased by 64% with high Glo1 expression. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Published 2017“…Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Published 2017“…Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. …”
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Allergenicity of roasted peanuts treated with a non-human digestive protease
Published 2015“…Results indicate that alcalase digestion of sonicated peanuts significantly increased protein solubility while decreasing Ara h 1 and Ara h 2 concentrations in both soluble and insoluble portions of peanuts relative to untreated peanuts. …”
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Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation
Published 2015“…Furthermore, we found that while both autophagy inhibitors abolished p38 phosphorylation, only CQ led to significant decrease in pERK1/2. Finally, RCE induced DNA damage and reduced mutant p53, two events that preceded autophagy. …”
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Corrosion inhibition of API X120 steel in a highly aggressive medium using stearamidopropyl dimethylamine
Published 2017“…The overall results showed that SAPDA significantly decreased the corrosion rate of API X120 steel with an inhibition efficiency of approximately 99% at an inhibitor concentration of 136 μmol L− 1. …”
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Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes
Published 2022“…In addition, DHA-treatment of hypoxic cells caused a significant reduction in the apoptosis rate and ROS production with decreased lipid peroxidation. Moreover, DHA-treatment of hypoxic cells caused a decreased secretion of pro-inflammatory markers (IL-6, MCP-1) and leptin and increased adiponectin secretion compared with hypoxic cells. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Published 2021“…Moreover, CSCs were localized in G0/G1-phase. Similarly, the tumor suppressor genes BRCA (40%), PTEN (25%), and p53 (36%) were downregulated. …”
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Usefulness of In-Situ Synchrotron Study on Scale Formation during CO2 Corrosion of Mild Steel: A Review
Published 2016“…Figure 2 shows the anodic current as a function of time in a potentiostatic test in the NaCl solution at pH 6.3 (pCO2 = 1bar) and an applied potential of ? 500 mV (vs SCE), together with the intensities of the Fe and FeCO3 signals from the in-situ synchrotron XRD [1]. …”
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Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
Published 2018“…There are two main EBV genotypes, Type 1 and 2, distinguished by the differences in the EBNA-2 gene. …”
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Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
Published 2020“…Results In high glucose concentration cultures, there was a ca. twofold increase in cellular MG, cellular protein MG-H1 content and decreased attachment of PDLFs to collagen-I. …”
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The role of type II FB (I):Tl+ defect in laser light generation and color image formation at the low coordination surface sites of AgBr: Ab initio calculations
Published 2006“…All relaxed excited states of the defect containing surfaces were deep below the lower edges of the conduction bands of the ground-state defect-free surfaces indicating that type II FB(I):Tl+ is suitable laser defect. The probability of orientational destruction of the two centers, attributed to the assumed saddle point ion configurations along the 〈1 1 0〉 axis, was found to decrease as the coordination number of the surface ions decreases. …”
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Enhancing the corrosion resistance of reinforcing steel under aggressive operational conditions using behentrimonium chloride
Published 2019“…Using only a 50 ?mol L?1 of BTC, we are able to measure an inhibition efficiency of 91, 79, and 71% in SCP solution with 3.5% NaCl at pH of 12.5, 10 and 7, respectively without showing any effect on the mechanical properties on the cured mortars. …”
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Effect of octylphenol polyethylene oxide on the corrosion inhibition of steel in 0.5 M H2SO4
Published 2004“…The experimental data were fitted with the Flory-Huggins isotherm at a molecular ratio of 5:1. The Gibbs energy of adsorption decreases with the temperature. …”
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