Showing 6,421 - 6,440 results of 27,447 for search '(( 10 ((teer decrease) OR (nn decrease)) ) OR ( 50 ((a decrease) OR (mean decrease)) ))', query time: 0.78s Refine Results
  1. 6421

    Ab Initio Prediction of Proton Exchange Barriers for Alkanes at Brønsted Sites of Zeolite H‑MFI by Marcin Rybicki (6077435)

    Published 2018
    “…A change to the indirect proton exchange mechanism, in which a hydride ion is transferred between the alkane and a <i>tert</i>-butyl carbenium ion can be excluded, because we confirm previous findings that the barrier for dehydrogenation that would create a <i>tert</i>-butyl cation from <i>i</i>-butane is much too high, 188 and 132 kJ/mol for the intrinsic and apparent enthalpy barriers, respectively, at 500 K. …”
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    Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

    Published 2021
    “…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI<sub>50</sub> of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”
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